Evidence map›Paper›PMID 40242369›Full record

ArticleOphthalmology science

Novel Risk Factors for Uveal Melanoma in Adolescent and Young Adult Patients: A Comprehensive Case-Control Analysis.

Arina Nisanova, Susanna S Park, Aana Amin, Carly Zako, Machelle D Wilson, Jessica Scholey, Armin R Afshar, Tony Tsai, Devron H Char, Kavita K Mishra

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arina NisanovaDepartment of Radiation Oncology, University of California San Francisco, San Francisco, California.
Susanna S ParkDepartment of Ophthalmology and Vision Science, University of California Davis, Sacramento, California.
Aana AminDepartment of Radiation Oncology, University of California San Francisco, San Francisco, California.
Carly ZakoDepartment of Radiation Oncology, University of California San Francisco, San Francisco, California.
Machelle D WilsonPublic Health Sciences, Division of Biostatistics, School of Medicine, University of California Davis, Sacramento, California.
Jessica ScholeyDepartment of Radiation Oncology, University of California San Francisco, San Francisco, California.
Armin R AfsharOcular Oncology Service, Department of Ophthalmology, University of California San Francisco, San Francisco, California.
Tony TsaiRetinal Consultants Medical Group, Sacramento, California.
Devron H CharTumori Foundation, San Francisco, California.
Kavita K MishraDepartment of Radiation Oncology, University of California San Francisco, San Francisco, California.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To identify risk factors associated with uveal melanoma (UM) in adolescents and young adults (AYAs). Design: A retrospective case-control study. Participants: Two hundred forty-seven UM patients aged 13 to 45 treated with proton beam radiation therapy and 401 age- and sex-matched controls at a tertiary academic center. Methods: We obtained demographic and genetic data, environmental exposures, and social, medical, and ocular history via retrospective chart review and phone follow-up. Main Outcome Measures: The main outcome measures included the prevalence and odds ratios (ORs) of the investigated risk factors in UM patients compared with controls. Results: The median age of UM diagnosis was 38 years (range: 13-45 years); the median follow-up was 102 months (range: 3-329 months). Identified novel risk factors for UM included family history of cutaneous melanoma (OR = 3.06, Conclusions: This study identified several novel risk factors for UM in AYAs and confirmed select established risk factors seen in UM patients of all ages. To the best of our knowledge, this is the first explicit and comprehensive investigation of risk factors among a younger cohort and may help further elucidate UM pathogenesis. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Adolescents and young adultsOcular melanomaProton beam radiation therapyRisk factorsUveal melanoma

Identifiers

PMID40242369
PMCPMC12002997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.