Evidence map›Paper›PMID 40242331›Full record

ArticleInternational biodeterioration & biodegradation2025

Environmentally-grown aerobic granular sludge performs more complete pharmaceutical biodegradation and wastewater treatment than lab-grown granules.

Kylie B Bodle, Catherine M Kirkland

Abstract read
In one paragraph

Article in International biodeterioration & biodegradation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kylie B BodleDepartment of Civil Engineering, 205 Cobleigh Hall, Montana State University, Bozeman, MT, USA.
Catherine M KirklandDepartment of Civil Engineering, 205 Cobleigh Hall, Montana State University, Bozeman, MT, USA.

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Ann Therese Bertagnolli · 2012 to 2026
$60.0M
Ultra Performance Liquid Chromatography Tandem Mass Spectrometer for MetabolomicsS10OD028650 · OD · MONTANA STATE UNIVERSITY - BOZEMAN · PI BOTHNER, BRIAN P · 2020 to 2020
$599k
NIGMS NIH HHS P20 GM103474NIH HHS S10 OD028650
6 · The paper itself

Abstract

This study evaluated pharmaceutical removal by environmentally-grown aerobic granular sludge (AGS). Most pharmaceutical treatment studies utilize lab-grown AGS, which is cultivated from activated sludge flocs on synthetic media and therefore is likely to possess different physical and microbiological properties than its real-world counterpart. For approximately 70 days, a 60 μg/L mixture of gemfibrozil, diclofenac, and erythromycin was fed to environmentally-grown AGS. Wastewater treatment, granule characteristics, and pharmaceutical fate were monitored. Environmentally-grown granules outperformed their lab-grown counterparts in multiple ways: environmental granules were physically unimpacted by pharmaceuticals, phosphate removal remained complete, and all nitrogen removal processes were unaffected except ammonia oxidation, which was temporarily inhibited by approximately 35%. Most importantly, gemfibrozil was completely biodegraded, a result yet to be observed in any AGS study. Diclofenac and erythromycin removal were minimal and generally below 10%. The families J111,

Indexed as

aerobic granular sludgebiodegradationmicrobial activitymicrobiomepharmaceuticalswastewater treatment

Identifiers

PMID40242331
PMCPMC11999665

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.