ArticleQuantitative imaging in medicine and surgery2025
Evaluation of low-dose chest scans for coronary artery calcium scoring using photon-counting computed tomography with different slice thicknesses and iterative reconstruction levels.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A scoping review of photon-counting detector computed tomography in cardiovascular imaging.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Article
- Application of the Novel Two-Compartmental Model to Quantify Coronary Artery Calcium: A Pilot Study.Journal of clinical medicine · 2026Article
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Authors and funding
9 authors.
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Abstract
Background: Coronary artery calcium scoring (CACS) is a noninvasive method for quantifying coronary artery calcification plaque burden. Although low-dose chest computed tomography (LD-CT) scans with energy-integrating detector CT can be used for CACS, its clinical utility is constrained by higher mean differences and wider limits of agreement. In contrast, photon-counting CT offers significantly enhanced image quality compared to energy-integrating detector CT, making it a more promising tool for accurate CACS. This study investigated the difference in CACS obtained from LD-CT using photon-counting detector CT as compared to standard CACS CT (CAC-CT). Methods: This prospective study included 105 patients (mean age 64.6±11.5 years) who underwent both CAC-CT and LD-CT scans on the same day using photon-counting detector CT. CAC-CT served as a reference standard. Ten groups generated by LD-CT were reconstructed using different strength levels of quantum iterative reconstruction (QIR; 0-4) and slice thickness (3 and 1.5 mm), with the LD Results: Coronary artery calcium was detected in 77 (73.3%) patients via CAC-CT. Each LD-CT group demonstrated high sensitivity (96.1-100%) and specificity (100%) in detecting coronary artery calcium, with all cases detected in the LD Conclusions: The LD-CT scan derived from photon-counting detector CT demonstrated excellent agreement with the standard CACS scan in terms of CACS and significantly reduced radiation dose. The reconstruction protocol using a 1.5-mm slice thickness with QIR level 1 improved coronary artery calcium detection, quantification, and risk categorization.
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