ArticleJournal of biomedical optics2025
Choice of numerical implementation of spatial contrast calculation impacts microcirculation quantitation in laser speckle contrast imaging.
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Significance: Laser speckle contrast imaging (LSCI) allows noninvasive imaging of microcirculation. Its scope of clinical applications is growing, yet the literature lacks a comparison of the accuracy of methods used to compute the spatial contrast Aim: We aim to evaluate the impact on flow quantitation of different computational approaches used to derive Approach: We compare numerical calculation of Results: For simulation data, we found variations of up to 58% for the blood flow index in the LSCI approach. Nonlinear fitting of the MESI model was less affected with discrepancies of only a few percent. Considering experimental data, the LSCI approximation led to Conclusions: Numerical methods used to calculate
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