Evidence map›Paper›PMID 40242085›Full record

ArticleRegenerative therapy2025

Co-culture with adipose mesenchymal stem cells promotes Blastocyst formation and gene expression in embryos from aged mice.

Yan-Der Hsuuw, Yu-Ting Su, Wen-Hsiung Chan, Cheng-Chun Wu, Yu-Chieh Tsai, Hou-Chun Chen, Fu-Jen Huang, Chuen-Fu Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yan-Der HsuuwDepartment of Tropical Agriculture and International Cooperation, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
Yu-Ting SuDepartment of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung City 83301, Taiwan.
Wen-Hsiung ChanDepartment of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Zhongbei Road, Zhongli District, Taoyuan City 32023, Taiwan.
Cheng-Chun WuSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung City 82445, Taiwan.
Yu-Chieh TsaiDepartment of Obstetrics and Gynecology, An- An Women and Children Clinic & ART Center, Kaohsiung City 80752, Taiwan.
Hou-Chun ChenLaboratory Animal Center, Office of Advanced Science and Technology, Thammasat University, Krung Thep Maha Nakhon 10200, Thailand.
Fu-Jen HuangDepartment of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung City 83301, Taiwan.
Chuen-Fu LinDepartment of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have highlighted the positive effects of co-culturing embryos with stem cells on embryo development in various mammalian systems. Stem cells secrete numerous factors, including cytokines, growth factors, and microRNAs, which promote embryo development. However, the impact of stem cells on the development of embryos derived from aged mice's oocytes remains poorly understood. This study evaluated the co-culture effects of adipose tissue-derived mesenchymal stem cells (ADMSCs) on zygotes, focusing on the developmental potential of fertilized embryos. Embryo quality was assessed through staining techniques to measure trophectoderm (TE), inner cell mass (ICM), and total blastocyst cell numbers during

Indexed as

BlastocystCo-cultureMesenchymal stem cellsZygotes

Identifiers

PMID40242085
PMCPMC12002604

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.