Evidence map›Paper›PMID 40242076›Full record

ArticleOpen forum infectious diseases2025

Pandemic Social Distancing and Declines in Nasopharyngeal Carriage of Pneumococcus and Related Antimicrobial-Resistant Genes: Evidence From Household-Based Cohort Studies in Lima, Peru.

Cara E Charnogursky, Ana I Gil, Lucie Ecker, Rubelio Cornejo, Stefano Rios, Mayra Ochoa, Bia Peña, Omar Flores, Angela Jones, Karen Beeri and 5 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Clinical microbiology reviews · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Cara E CharnogurskyDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-8911-1377
Ana I GilInstituto de Investigación Nutricional, Lima, Peru.ORCID https://orcid.org/0000-0003-0840-4483
Lucie EckerInstituto de Investigación Nutricional, Lima, Peru.ORCID https://orcid.org/0000-0001-6887-2356
Rubelio CornejoInstituto de Investigación Nutricional, Lima, Peru.
Stefano RiosInstituto de Investigación Nutricional, Lima, Peru.
Mayra OchoaInstituto de Investigación Nutricional, Lima, Peru.
Bia PeñaInstituto de Investigación Nutricional, Lima, Peru.
Omar FloresInstituto de Investigación Nutricional, Lima, Peru.
Angela JonesVanderbilt Technologies for Advanced Genomics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-1565-4360
Karen BeeriVanderbilt Technologies for Advanced Genomics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Huiding ChenDepartment of Biostatistics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA.
Qingxia ChenDepartment of Biostatistics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0003-0507-1847
Claudio F LanataDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-6994-7425
Leigh M HowardDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0003-4301-7235
Carlos G GrijalvaDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA.

Funding

Mentoring in transmission of influenza and strategies for preventionK24AI148459 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRIJALVA, CARLOS G · 2020 to 2024
$893k
Impact of Pandemic Mitigation Efforts on Colonization and Transmission of Respiratory Pathogens and Antibiotic Resistance GenesR21AI171901 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRIJALVA, CARLOS G, HOWARD, LEIGH MEREDITH · 2022 to 2023
$476k
NIAID NIH HHS K24 AI148459NIAID NIH HHS R21 AI171901
6 · The paper itself

Abstract

Background: Peru implemented restrictive social distancing policies during the COVID-19 pandemic. Few studies have examined patterns of nasopharyngeal pneumococcal carriage and related antimicrobial-resistant genes (ARGs), particularly in community-based settings with intense social distancing policies. Methods: Nasopharyngeal swabs were systematically obtained weekly from children and adults enrolled in 2 household-based prospective cohorts in Lima, Peru: prepandemic (2019-2020) and pandemic (2020-2021). Selected samples underwent sequencing-based detection of Results: An overall 663 specimens from 114 individuals were included: 407 and 256 samples from the prepandemic and pandemic cohorts, respectively. Carriage of pneumococcus was lower in the pandemic cohort (3.5%) as compared with the prepandemic cohort (23.6%; adjusted odds ratio, 0.09; 95% CI, .02-.32). Similarly, Conclusions: We observed a substantial reduction in the carriage of

Indexed as

antibiotic resistance genescolonizationCOVID-19 pandemicnext-generation sequencingpneumococcus

Identifiers

PMID40242076
PMCPMC12000526

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.