Evidence map›Paper›PMID 40242065›Full record

ArticleOpen forum infectious diseases2025

Cardiometabolic Biomarkers and Systemic Inflammation in US Adolescents and Young Adults With Latent Tuberculosis Infection: A Population-Based Cohort Study.

Itai M Magodoro, Ntobeko A B Ntusi, Jennifer Jao, Heather J Zar, Brian L Claggett, Mark J Siedner, Katalin A Wilkinson, Robert J Wilkinson

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Itai M MagodoroDepartment of Medicine, University of Cape Town, Observatory, Republic of South Africa.ORCID https://orcid.org/0000-0002-3879-6126
Ntobeko A B NtusiDepartment of Medicine, University of Cape Town, Observatory, Republic of South Africa.ORCID https://orcid.org/0000-0003-2347-7883
Jennifer JaoDivision of Pediatric Infectious Diseases, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Heather J ZarSAMRC Extramural Unit of Child and Adolescent Health, University of Cape Town, Rondebosch, Republic of South Africa.ORCID https://orcid.org/0000-0002-9046-759X
Brian L ClaggettHarvard Medical School, Boston, Massachusetts, USA.
Mark J SiednerHarvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-3506-842X
Katalin A WilkinsonDepartment of Medicine, University of Cape Town, Observatory, Republic of South Africa.ORCID https://orcid.org/0000-0002-9796-2040
Robert J WilkinsonDepartment of Medicine, University of Cape Town, Observatory, Republic of South Africa.ORCID https://orcid.org/0000-0002-2753-1800

Funding

Cape Town Adolescent Antiretroviral Cohort (CTAAC)R01HD074051 · NICHD · UNIVERSITY OF CAPE TOWN · PI ZAR, HEATHER JOY · 2012 to 2016
$3.0M
Mentoring patient-oriented research to improve cardiovascular health among people with HIV in sub-Saharan AfricaK24HL166024 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 2022 to 2026
$616k
NHLBI NIH HHS K24 HL166024NICHD NIH HHS R01 HD074051
6 · The paper itself

Abstract

Background: Methods: Peripubescent adolescents (12-15 years old) and older adolescents/young adults (16-30 years old) were assessed for LTBI by tuberculin skin testing (induration ≥10 mm). Outcomes included fasting plasma glucose, hemoglobin A Results: Seventy-five LTBI cases were matched to 300 peers who were TB uninfected. Among older participants, LTBI was associated with higher inflammation (adjusted median [IQR]: C-reactive protein, 0.22 mg/dL [0.05-0.34] vs 0.11 [0.04-0.35], Conclusions: Older adolescents and young adults with LTBI had higher inflammation than those without LTBI, while cardiometabolic profiles were similar. Unlike that in adults,

Indexed as

adolescentscardiometabolic diseaseinflammationLTBIyoung adults

Identifiers

PMID40242065
PMCPMC12002011

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.