ArticleJHLT open2025
Bridging to orthotopic heart transplant: Reducing the risk of intra-operative blood loss.
Article in JHLT open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Background: Orthotopic heart transplantation remains the gold standard for patients with end-stage heart failure. Many devices exist to bridge patients with heart failure to transplant. Impella 5.5 (Abiomed, Danvers MA) is an example of a temporary mechanical assist device, which prioritizes patients as Status 2 by the 2018 UNOS policy change, increasing their likelihood of transplantation. Given the increase in device use, we sought to compare intra-operative complications, particularly blood loss, between bridging strategies to transplantation. Methods: We conducted a single-institution retrospective analysis between January 2019 and May 2023. Results: A transfusion requirement was defined as greater than 4 units of blood given intra- or immediately post-operatively (24%, 22/93). The transfusion group was more likely to have had a prior sternotomy (82% vs. 48% Conclusion: The shift to prioritize bridging devices has not been met with an increased risk of blood transfusion. We found that parameters such as a prior sternotomy, duration of temporary mechanical assist device (tMCS) use, and the presence of an LVAD were associated. This represents the first study to compare intra- and immediately post-operative transfusion data between bridging devices in the setting of transplantation.
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