Evidence map›Paper›PMID 40242012›Full record

ReviewRevista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia2025

Clinical repercussions of statin use during pregnancy: a review of the literature.

Joan Lins Serafim, Pedro Lucas Santos de Menezes Teles, Amanda Katharinne Souza Lima, Jéssica Dos Santos Coelho, Paloma Luna Maranhão Conrado, Valda Lúcia Moreira Luna, Pauliana Valéria Machado Galvão, George Alessandro Maranhão Conrado

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joan Lins SerafimUniversidade de Pernambuco RecifePE Brazil Universidade de Pernambuco, Recife, PE, Brazil.ORCID https://orcid.org/0000-0001-9916-2437
Pedro Lucas Santos de Menezes TelesUniversidade de Pernambuco RecifePE Brazil Universidade de Pernambuco, Recife, PE, Brazil.ORCID https://orcid.org/0009-0003-7151-878X
Amanda Katharinne Souza LimaUniversidade de Pernambuco RecifePE Brazil Universidade de Pernambuco, Recife, PE, Brazil.ORCID https://orcid.org/0000-0002-3895-2889
Jéssica Dos Santos CoelhoUniversidade de Pernambuco RecifePE Brazil Universidade de Pernambuco, Recife, PE, Brazil.ORCID https://orcid.org/0000-0001-9541-0798
Paloma Luna Maranhão ConradoUniversidade de Pernambuco RecifePE Brazil Universidade de Pernambuco, Recife, PE, Brazil.ORCID https://orcid.org/0000-0001-8828-667X
Valda Lúcia Moreira LunaUniversidade de Pernambuco RecifePE Brazil Universidade de Pernambuco, Recife, PE, Brazil.ORCID https://orcid.org/0000-0002-1810-7565
Pauliana Valéria Machado GalvãoUniversidade de Pernambuco RecifePE Brazil Universidade de Pernambuco, Recife, PE, Brazil.ORCID https://orcid.org/0000-0002-4418-218X
George Alessandro Maranhão ConradoUniversidade de Pernambuco RecifePE Brazil Universidade de Pernambuco, Recife, PE, Brazil.ORCID https://orcid.org/0000-0001-6649-577X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Statins are the most widely used pharmacological class for treating hyperlipidemia, although they are contraindicated during pregnancy. This study aims to demonstrate the clinical effects of statins in pregnant women through an interactive review. Fifteen original articles were selected, in English or Portuguese, within of five years. Statins have not been associated with the development of fetal malformations and their use may be useful in preventing unfavorable cardiovascular outcomes, with the potential to reduce oxidative stress and angiogenic dysfunction. However, the use of statins to prevent pre-eclampsia in humans has not been properly clarified and further studies are needed. Pravastatin is considered safer than statins for use during pregnancy.

Indexed as

Hydroxymethylglutaryl-CoA Reductase InhibitorsPregnancy ComplicationsFemaleHumansPregnancyHydroxymethylglutaryl-CoA Reductase InhibitorsAntihypertensive agentsHydroxymethylglutaryl-CoA reductase inhibitorsPravastatinPre-eclampsiaPregnancyPregnant woman

Identifiers

PMID40242012
PMCPMC12002716

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.