Evidence map›Paper›PMID 40241981›Full record

ArticleHealth care science2025

Plasma Lipidomics Profiling of Developmental Dysplasia of the Hip in Tibet Plateau.

Xiaogang Li, Jiamei Ji, Ping Li, De Yang, Nyima Yedron, Yanming Lei, Tao Chen, Jianchu Li, Ye Guo, Xiao Yang and 2 more

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In one paragraph

Article in Health care science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaogang LiBiobank Facility, National Infrastructures for Translational Medicine, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing China.
Jiamei JiDepartment of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China.
Ping LiDepartment of Orthopedics People's Hospital of Tibet Autonomous Region Lhasa Tibet China.
De YangDepartment of Ultrasound People's Hospital of Tibet Autonomous Region Lhasa Tibet China.
Nyima YedronDepartment of Ultrasound People's Hospital of Tibet Autonomous Region Lhasa Tibet China.
Yanming LeiDepartment of Radiology People's Hospital of Tibet Autonomous Region Lhasa Tibet China.
Tao ChenDepartment of Ultrasound, Beijing Jishuitan Hospital, The 4th Clinical College Peking University Beijing China.
Jianchu LiDepartment of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China.
Ye GuoState Key Laboratory of Complex Severe and Rare Diseases, Department of Clinical Laboratory, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China.
Xiao YangDepartment of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China.ORCID 0000-0002-6454-5398
Li ShiDepartment of Infectious Diseases People's Hospital of Tibet Autonomous Region Lhasa Tibet China.
Dan QuDepartment of Laboratory Medicine People's Hospital of Tibet Autonomous Region Lhasa Tibet China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Developmental dysplasia of the hip (DDH) is a prevalent pediatric condition with a multifactorial etiology. Its incidence varies geographically, with notably higher rates observed on the Tibet plateau. This study was performed to evaluate the lipidomics signatures associated with DDH by analyzing plasma samples. Methods: Fifty infants were recruited, including 25 diagnosed with DDH and 25 age-matched healthy controls. In addition to plasma samples, comprehensive laboratory test results and medical records were collected for each participant. An untargeted lipidomics profiling approach was employed to identify distinguishing metabolic signatures. Results: Lipidomics profiles differed significantly between patients with DDH and healthy controls. Several differential metabolites were identified, including triacylglycerol (TAG)(17:0/18:1/20:1), TAG(17:0/17:0/17:0), phosphatidylethanolamine (PE)(10:0/26:4), TAG(17:0/18:0/18:0), TAG(16:0/17:0/22:1), TAG(16:0/18:0/22:0), TAG(17:0/19:0/19:0), TAG(13:0/20:0/20:0), TAG(18:0/18:0/22:0), and TAG(16:0/20:0/20:0). The primary lipid species showing differences were TAGs and PE. Conclusions: Distinct shifts in lipidomics profiles were observed in infants with DDH. To the best of our knowledge, this study is the first to explore lipidomics signatures in patients with DDH. The combined assessment of TAG(17:0/18:1/20:1) and TAG(17:0/17:0/17:0) may serve as a potential diagnostic tool for DDH.

Indexed as

developmental dysplasia of the hipdiagnosislipidomicspediatric orthopedicphosphatidylethanolaminetriacylglycerols

Identifiers

PMID40241981
PMCPMC11997466

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