ArticleInternational journal of nursing sciences2025
Exploring core symptoms and symptom clusters among patients with neuromyelitis optica spectrum disorder: A network analysis.
Article in International journal of nursing sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Movement Disorders in Neuromyelitis Optica Spectrum Disorder: A Systematic Review.Movement disorders clinical practice · 2026Pooled it
- Network Analysis of Contemporaneous Symptoms and Identification of Core Symptoms in Patients with Lumbar Disc Herniation.Journal of pain research · 2025Article
- Symptom clusters mediate anxiety/depression effects on quality of life in neuromyelitis optica spectrum disorders: a cross-sectional mediation analysis.Frontiers in neurologyArticle
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To identify core symptoms and symptom clusters in patients with neuromyelitis optica spectrum disorder (NMOSD) by network analysis. Methods: From October 10 to 30, 2023, 140 patients with NMOSD were selected to participate in this online questionnaire survey. The survey tools included a general information questionnaire and a self-made NMOSD symptoms scale, which included the prevalence, severity, and distress of 29 symptoms. Cluster analysis was used to identify symptom clusters, and network analysis was used to analyze the symptom network and node characteristics and central indicators including strength centrality ( Results: The most common symptom was pain (65.7%), followed by paraesthesia (65.0%), fatigue (65.0%), easy awakening (63.6%). Regarding the burden level of symptoms, pain was the most burdensome symptom, followed by paraesthesia, easy awakening, fatigue, and difficulty falling asleep. Six clusters were identified: somatosensory, motor, visual, and memory symptom clusters, bladder and rectum symptom clusters, sleep symptoms clusters, and neuropsychological symptom clusters. Fatigue ( Conclusions: Our study demonstrated the necessity of symptom management targeting fatigue, pain, and motor symptom cluster in patients with NMOSD.
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