Evidence map›Paper›PMID 40241651›Full record

ArticleJournal of leukocyte biology2025

UDP-glucose regulates dendritic cell mitochondrial respiration via a nitric oxide-dependent mechanism.

Bay Vagher, Soyeon K Gullickson, Julia P Snyder, Tyler Hogan, Roxana Del Rio-Guerra, Keke C Fairfax, Eyal Amiel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of leukocyte biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bay VagherCellular, Molecular, and Biomedical Sciences Graduate Program, University of Vermont, 106 Carrigan Drive, Burlington, VT 05405, United States.
Soyeon K GullicksonCellular, Molecular, and Biomedical Sciences Graduate Program, University of Vermont, 106 Carrigan Drive, Burlington, VT 05405, United States.
Julia P SnyderCellular, Molecular, and Biomedical Sciences Graduate Program, University of Vermont, 106 Carrigan Drive, Burlington, VT 05405, United States.
Tyler HoganCellular, Molecular, and Biomedical Sciences Graduate Program, University of Vermont, 106 Carrigan Drive, Burlington, VT 05405, United States.
Roxana Del Rio-GuerraFlow Cytometry and Cell Sorting Facility, Larner College of Medicine, University of Vermont, 106 Carrigan Drive, Burlington, VT 05405, United States.
Keke C FairfaxDivision of Microbiology and Immunology, Department of Pathology, University of Utah, 5 North Medical Drive East, Salt Lake City, UT 84112, United States.
Eyal AmielCellular, Molecular, and Biomedical Sciences Graduate Program, University of Vermont, 106 Carrigan Drive, Burlington, VT 05405, United States.ORCID 0000-0002-1578-8705

Funding

Vermont Immunology/Infectious Diseases CenterP30GM118228 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2016 to 2021
$6.8M
Durable Schistosome induced metabolic alterations to the myeloid lineageR01AI158710 · NIAID · UNIVERSITY OF UTAH · PI AMIEL, EYAL, FAIRFAX, KEKE CELESTE · 2021 to 2024
$2.3M
The Role of Glycogen Metabolism in Supporting Dendritic Cell Immune FunctionR21AI135385 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI AMIEL, EYAL · 2018 to 2019
$422k
National Institute of Allergy and Infectious Diseases 1R21AI135385-01ANational Institute of Allergy and Infectious Diseases P30GM118228National Institute of Allergy and Infectious Diseases R01 AI158710-01NIAID NIH HHS R01 AI158710NIAID NIH HHS R21 AI135385NIGMS NIH HHS P30 GM118228NIH HHS
6 · The paper itself

Abstract

Bone marrow-derived dendritic cell (BMDC) activation is associated with rewiring of cellular metabolism and concurrent large-scale changes in gene expression promoting a proinflammatory program characterized by expression of inducible nitric oxide synthase and the production of nitric oxide (NO). NO inhibits vital cellular activities including mitochondrial respiration. Mitochondrial respiration inhibition via NO occurs at discrete levels of activating stimulus, termed the mitochondrial respiration threshold, and regulation of this threshold is not fully understood. In this work, we characterize the role of uridine diphosphate glucose as a modulator of NO-mediated mitochondrial respiration inhibition via P2Y14 receptor signaling in stimulated BMDCs. We demonstrate that BMDCs exhibit an enhanced proinflammatory profile in the presence of uridine diphosphate glucose, providing evidence for a new NO regulatory axis in BMDCs. These studies highlight the importance of the growing body of literature supporting metabolites as signaling molecules in activating conditions thus allowing for better modeling of physiologically relevant contexts for myeloid cell encounters with microbial stimuli.

Indexed as

Dendritic CellsMitochondriaNitric OxideUridine Diphosphate GlucoseAnimalsCell RespirationMiceMice, Inbred C57BLReceptors, Purinergic P2Signal TransductionNitric OxideReceptors, Purinergic P2Uridine Diphosphate Glucosebone marrow–derived dendritic cellsnitric oxideNOreal-time extracellular flux analysisseahorse

Identifiers

PMID40241651
PMCPMC12089799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.