Evidence map›Paper›PMID 40241609›Full record

ArticleAmerican journal of physiology. Renal physiology2025

Renal ischemia alters the mRNA and miRNA profile of vasculature-related genes in scattered tubular-like cells from female pigs.

Sara Kazeminia, Kamalnath S Rajagopalan, Xiang-Yang Zhu, Hui Tang, Alejandro R Chade, Maria V Irazabal, Lilach O Lerman, Alfonso Eirin

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sara KazeminiaDepartment of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-2621-9962
Kamalnath S RajagopalanDepartment of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States.
Xiang-Yang ZhuDepartment of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States.
Hui TangDepartment of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States.
Alejandro R ChadeDepartment of Medical Pharmacology and Physiology and Department of Medicine, University of Missouri-Columbia, Columbia, Missouri, United States.
Maria V IrazabalDepartment of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-9904-7778
Lilach O LermanDepartment of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-3271-3887
Alfonso EirinDepartment of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-3864-9644

Funding

Obesity-induced dysfunction of human MSC in peripheral microvascular repairR01HL158691 · NHLBI · MAYO CLINIC ROCHESTER · PI Alfonso Eirin, Lilach O Lerman · 2022 to 2026
$3.4M
Role of mitochondrial microRNAs (mitomiRs) in endogenous renal repairR01DK129240 · NIDDK · MAYO CLINIC ROCHESTER · PI Alfonso Eirin · 2023 to 2026
$1.8M
A new large pre-clinical model of aging-related heart failure: a platform to develop new therapies for HFpEFR21AG084154 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHADE, ALEJANDRO ROBERTO · 2023 to 2023
$460k
Role of mitochondrial microRNAs (mitomiRs) in endogenous renal repairR56DK129240 · NIDDK · MAYO CLINIC ROCHESTER · PI EIRIN, ALFONSO · 2021 to 2021
$100k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL158691HHS | NIH | National Institute on Aging (NIA) AG084154HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK129240NHLBI NIH HHS R01 HL158691NIA NIH HHS R21 AG084154NIDDK NIH HHS R01 DK129240NIDDK NIH HHS R56 DK129240Regenerative Medicine Minnesota (RMM) RMM 091620 DS 004
6 · The paper itself

Abstract

Scattered tubular-like cells (STCs) are renal tubular cells that survive episodes of renal injury and acquire progenitor-like characteristics to repair other damaged kidney cells. STCs release proangiogenic factors in culture and induce microvascular proliferation in injured murine kidneys in vivo. Renovascular disease (RVD) compromises the reparative capacity of STCs, but the underlying mechanisms remain unknown. We hypothesized that RVD alters the expression of vasculature-related genes in swine STCs and impair their vasculoprotective properties. CD24

Indexed as

IschemiaKidney TubulesMicroRNAsNeovascularization, PhysiologicRNA, MessengerAnimalsDisease Models, AnimalFemaleHumansHuman Umbilical Vein Endothelial CellsSwineTranscriptomeMicroRNAsRNA, MessengerangiogenesismiRNAmRNArenal ischemiascattered tubular-like cells

Identifiers

PMID40241609
PMCPMC12120692

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.