Evidence map›Paper›PMID 40241493›Full record

Trial reportJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2025

Ultrasound Neuromodulation (Low-Intensity Focused Ultrasound) to Treat Knee Osteoarthritis Pain: A Randomized, Observer- and Participant-Masked, Sham-Controlled, Human-Subjects Pilot Study.

Brian M Ilfeld, Khoa N Cao, Ruben Branson, Philip Bloom

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07572591 (Assessment of Wearable Ultrasound for Modulation), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07572591 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Assessment of Wearable Ultrasound for Modulation

TypeinterventionalSponsorStanford UniversityRan2026 to 2027Enrolled90ConditionsNeuropathic Pain, Chronic PainArmsUltrasound, Sham (No Treatment)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brian M IlfeldDepartment of Anesthesiology and Outcomes Research, University California San Diego, San Diego, CA, USA.ORCID https://orcid.org/0000-0002-6144-3273
Khoa N CaoFaculties of Medicine, Nursing and Health Sciences & Engineering, Monash University, Melbourne, Victoria, Australia.
Ruben BransonSportsMed Biologic, Box Hill, Victoria, Australia.
Philip BloomSportsMed Biologic, Box Hill, Victoria, Australia.

Funding

Pegasus Neurotechnology
6 · The paper itself

Abstract

Low-intensity focused ultrasound is a non-invasive neuromodulation technique that delivers mechanical forces to a deep location within the body through acoustic pressure waves without affecting tissue between the transducer and focal target. Preliminary studies involving healthy volunteers suggest focused ultrasound reversibly prevents action potential formation similar to a local anesthetic nerve block, but the modality has not been used in patients with existing pain. The current randomized pilot study was undertaken to 1) determine the feasibility and optimize the protocol for a subsequent definitive clinical trial; and 2) monitor for related complications of focused ultrasound when treating knee osteoarthritis pain.

Indexed as

Osteoarthritis, KneePain ManagementUltrasonic TherapyAdultAgedFemaleHumansMaleMiddle AgedPain MeasurementPilot ProjectsTreatment Outcomeanalgesiachronic painpain management

Identifiers

PMID40241493
PMCPMC12327162

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.