Evidence map›Paper›PMID 40241474›Full record

ArticleJournal of pineal research2025

Melatonin and Exercise Restore Myogenesis and Mitochondrial Dynamics Deficits Associated With Sarcopenia in iMS-Bmal1

Yolanda Ramírez-Casas, José Fernández-Martínez, María Martín-Estebané, Paula Aranda-Martínez, Alba López-Rodríguez, Sergio Esquivel-Ruiz, Yang Yang, Germaine Escames, Darío Acuña-Castroviejo

Abstract read
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In one paragraph

Article in Journal of pineal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yolanda Ramírez-CasasCentro de Investigación Biomédica, Facultad de Medicina, Departamento de Fisiología, Instituto de Biotecnología, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Granada, Spain.ORCID http://orcid.org/0000-0002-5855-0449
José Fernández-MartínezCentro de Investigación Biomédica, Facultad de Medicina, Departamento de Fisiología, Instituto de Biotecnología, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Granada, Spain.ORCID http://orcid.org/0000-0002-5593-6733
María Martín-EstebanéCentro de Investigación Biomédica, Facultad de Medicina, Departamento de Fisiología, Instituto de Biotecnología, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Granada, Spain.ORCID http://orcid.org/0000-0002-9680-581X
Paula Aranda-MartínezCentro de Investigación Biomédica, Facultad de Medicina, Departamento de Fisiología, Instituto de Biotecnología, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Granada, Spain.ORCID http://orcid.org/0000-0002-1171-010X
Alba López-RodríguezCentro de Investigación Biomédica, Facultad de Medicina, Departamento de Fisiología, Instituto de Biotecnología, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Granada, Spain.ORCID http://orcid.org/0000-0001-7407-8802
Sergio Esquivel-RuizCentro de Investigación Biomédica, Facultad de Medicina, Departamento de Fisiología, Instituto de Biotecnología, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Granada, Spain.ORCID http://orcid.org/0000-0002-9255-7222
Yang YangKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China.ORCID http://orcid.org/0000-0002-1163-2359
Germaine EscamesCentro de Investigación Biomédica, Facultad de Medicina, Departamento de Fisiología, Instituto de Biotecnología, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Granada, Spain.ORCID http://orcid.org/0000-0003-1256-7656
Darío Acuña-CastroviejoCentro de Investigación Biomédica, Facultad de Medicina, Departamento de Fisiología, Instituto de Biotecnología, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Granada, Spain.ORCID http://orcid.org/0000-0002-9680-1560

Funding

This study was partially supported by grants from the Instituto de Salud Carlos III through the grants PI19-01372 and CB/10/00238 (Co-funded by European Regional Development Fund/European Social Fund "Investing in your future"); the Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (CTS-101), Spain, and the UGC de Laboratorios Clínicos, Hospital Universitario San Cecilio, Granada, Spain. Y.R.-C. has a PFIS fellowship from the Instituto de Salud Carlos III; J.F.-M is supported by a FPU fellowship from the Ministerio de Educación, Spain; and P.A.-M. has a fellowship from grant no. P18-RT-698.
6 · The paper itself

Abstract

Sarcopenia, a condition associated with aging, involves progressive loss of muscle mass, strength, and function, leading to impaired mobility, health, and increased mortality. The underlying mechanisms remain unclear, which limits the development of effective therapeutic interventions. Emerging evidence implicates chronodisruption as a key contributor to sarcopenia, emphasizing the role of Bmal1, a circadian clock gene critical for muscle integrity and mitochondrial function. In a skeletal muscle-specific and inducible Bmal1 knockout model (iMS-Bmal1

Indexed as

ARNTL Transcription FactorsMelatoninMitochondrial DynamicsMuscle DevelopmentPhysical Conditioning, AnimalSarcopeniaAnimalsMaleMiceMice, KnockoutMuscle, SkeletalARNTL Transcription FactorsBmal1 protein, mouseMelatoninBmal1exercisemelatoninmitochondrial dysfunctionmyogenesissarcopeniaskeletal muscle

Identifiers

PMID40241474
PMCPMC12117299

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.