Trial reportJournal of the Chinese Medical Association : JCMA2025
Effects of Ban-Xia-Hou-Pu-Tang and Western medicine on patients with globus sensation: A randomized controlled trial.
Trial report in Journal of the Chinese Medical Association : JCMA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Adjunctive Use of VGH4 for Moderate-to-Severe Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Crossover Pilot Trial.Life (Basel, Switzerland) · 2026Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundGlobus, a non-painful sensation of a lump in the throat, affects nearly half of the population. Its etiology remains uncertain, and standardized treatment is lacking. Ban-Xia-Hou-Pu-Tang (BXHPT, ), a classical formula for "Plum Pit Qi" ( ), closely resembles globus in traditional Chinese medicine. This study investigated the traditional Chinese medicine constitution of patients with globus and evaluated the efficacy and safety of BXHPT combined with western therapy.
methodsA single-blinded, randomized, placebo-controlled trial was conducted in patients with globus pharyngeus. Participants received either fexofenadine, famotidine, and acetylcysteine plus BXHPT (group A) or plus placebo (group B) for 4 weeks. The Constitution in Chinese Medicine Questionnaire, Reflux Symptom Index (RSI), Glasgow Edinburgh Throat Scale (GETS), Beck Anxiety Inventory (BAI), Beck Depression Inventory-II (BDI-II), and Reflux Finding Score (RFS) were assessed. Hepatic and renal safety were monitored.
resultsNinety-two patients completed the trial. Both groups showed significant improvements in RFS, RSI, GETS, BAI, and BDI-II. Group A had greater RFS reduction at week 2 (8.03 ± 1.57 vs 10.12 ± 1.75; p < 0.001) and week 4 (7.43 ± 1.16 vs 9.17 ± 1.80, p = 0.007). No hepatic or renal adverse effects occurred.
conclusionBXHPT combined with western therapy provided additional improvement in laryngoscopic findings without safety concerns, supporting its potential as an effective adjunctive treatment for globus sensation.
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