Evidence map›Paper›PMID 40241352›Full record

ArticleHead & neck2025

Acoustic Features of Airway Protective Maneuvers as Biomarkers of Radiation-Associated Dysphagia and Penetration/Aspiration in Head and Neck Cancer Patients.

Sofiana Mootassim-Billah, Jean Schoentgen, Marc De Bodt, Hichem Slama, Esther Willemse, Tatiana Dragan, Nicolas Roper, Mathilde Le Tensorer, Paulus Kristanto, Marianne Paesmans and 2 more

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In one paragraph

Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Sofiana Mootassim-BillahDepartment of Radiation Oncology, Speech Therapy Unit, Institut Jules Bordet, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Brussels, Belgium.
Jean SchoentgenDepartment of Biomechatronics, Université Libre de Bruxelles, Brussels, Belgium.
Marc De BodtDepartment of Otolaryngology and Head and Neck Surgery, University Rehabilitation Center for Communication Disorders, Antwerp University Hospital, Antwerp, Belgium; Department of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Department of Logopaedics and Audiological Sciences, Faculty of Medicine and Health Sciences, University of Ghent, Ghent, Belgium.
Hichem SlamaDepartment of Neuropsychology and Speech Therapy, CUB Hôpital Erasme, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Brussels, Belgium; UR2NF, Neuropsychology and Functional Neuroimaging Research Unit at CRCN, Centre de Recherches en Cognition et Neurosciences, Brussels, Belgium.
Esther WillemseDepartment of Head and Neck Surgery, Jules Bordet Institute, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Brussels, Belgium.
Tatiana DraganDepartment of Radiation Oncology (Head and Neck Unit), Institut Jules Bordet, Hopital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Brussels, Belgium.
Nicolas RoperDepartment of ENT and Head & Neck Surgery, Hopital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Brussels, Belgium.
Mathilde Le TensorerDepartment of Neuropsychology and Speech Therapy, Institut Jules Bordet, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Brussels, Belgium.
Paulus KristantoData Center, Unité de Gestion de L'information (UGI), Institut Jules Bordet, Hôpital Universitaire de Bruxelles (HUB), Brussels, Belgium.
Marianne PaesmansData Center, Unité de Gestion de L'information (UGI), Institut Jules Bordet, Hôpital Universitaire de Bruxelles (HUB), Brussels, Belgium.
Dirk Van GestelRadiation-Oncologist, Université Libre de Bruxelles, Brussels, Belgium.
Gwen Van NuffelenDepartment of Otolaryngology and Head and Neck Surgery, University Rehabilitation Center for Communication Disorders, Antwerp University Hospital, Antwerp, Belgium; Department of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Department of Logopaedics and Audiological Sciences, Faculty of Medicine and Health Sciences, University of Ghent, Ghent, Belgium.

Funding

Association Jules Bordet
6 · The paper itself

Abstract

backgroundThis study aimed at identifying acoustic features of airway protective maneuvers as biomarkers of radiation-associated dysphagia, involving penetration/aspiration and pharyngeal residue.

methodsTemporal and spectral acoustical analyses were carried out on voluntary coughs, voluntary throat clearings, and reflexive coughs. Head and neck cancer patients with and without penetration/aspiration were compared. The same was done for patients and healthy controls.

resultsA decreased convexity of the amplitude contour and decreased salience of periodicity in the frequency band 0-400 Hz were observed in induced reflexive coughs of patients compared to healthy controls. A longer length and a less steep slope of the amplitude contour of voluntary throat clearings were observed in patients with penetration/aspiration versus those without.

conclusionsAcoustic features of induced reflexive cough discriminate between patients and healthy controls, but do not relate to penetration/aspiration. However, acoustic features of voluntary throat clearing are associated with penetration/aspiration in head and neck cancer patients.

Indexed as

Deglutition DisordersHead and Neck NeoplasmsRadiation InjuriesRespiratory AspirationAcousticsAdultAgedBiomarkersCase-Control StudiesCoughFemaleHumansMaleMiddle AgedBiomarkersacoustic featuresairway protective maneuvershead and neck cancer patientspenetration/aspirationradiation‐associated dysphagia

Identifiers

PMID40241352
PMCPMC12338026

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.