Trial reportActa anaesthesiologica Scandinavica2025
The impact of blood pressure targets on venous return physiology during post cardiac arrest care.
Trial report in Acta anaesthesiologica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- The impact of blood pressure targets on haemodynamics in patients with cardiogenic shock caused by infarction-related out-of-hospital cardiac arrest: a substudy of the BOX-trial.European heart journal. Acute cardiovascular care · 2026Trial
- Impact of Higher Versus Lower Blood Pressure Targets on Pulmonary Vascular Hemodynamics During Intensive Care After Out-of-Hospital Cardiac Arrest.Acta anaesthesiologica Scandinavica · 2026Trial
- The impact of blood pressure targets on venous return physiology during post cardiac arrest care.Acta anaesthesiologica Scandinavica · 2025Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundVenous return (VR) physiology may be elucidated using a calculated mean systemic filling pressure analogue (P
methodsThis exploratory study used data from the BOX trial that investigated a higher (MAP of 77 mmHg, MAP77) versus a lower (63 mmHg, MAP63) blood pressure target during intensive care of survivors from out-of-hospital cardiac arrest. Data from 730 patients (MAP63, n = 362 and MAP77, n = 368) were used to calculate P
resultsThe P
conclusionIn conclusion, a higher MAP target effectively increased the stressed intravascular volume to sustain a higher CO. EDITORIAL COMMENT: This post-hoc analysis of the BOX trial explores VR physiology and how it is influenced by the use of various doses of noradrenaline and dopamine. A higher blood pressure target appears to increase VR by increasing the stressed intravascular volume. This results in an increase in the CO. These findings are important given the worry about the effect of a higher afterload on cardiac function.
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