Evidence map›Paper›PMID 40241284›Full record

ArticlePlant, cell & environment2026

OsEPSPS Balances Disease Resistance and Plant Growth.

Kaiwei He, Liting Xu, Xiaobo Zhu, Wei Zhang, Lifen Ren, Yuchen Liu, Chunyu Guo, Yahuan Ma, Qian Yi, Yingzhi Xu and 9 more

Abstract read
PubMed Full text at PMC Publisher
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Article in Plant, cell & environment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

19 authors.

Kaiwei HeState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.
Liting XuState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.
Xiaobo ZhuState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.
Wei ZhangState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.
Lifen RenState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.
Yuchen LiuState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.
Chunyu GuoState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.
Yahuan MaState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.
Qian YiState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.
Yingzhi XuState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.
Junjie YinState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.
Xiumei LuoInstitute of Urban Agriculture, Chinese Academy of Agricultural Sciences; Chengdu Agricultural Science and Technology Center, Chengdu, China.
Lijuan ZouEcological Security and Protection Key Laboratory of Sichuan Province, Mianyang Teachers' College, Mianyang, China.
Li SongState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.
Xiang LuState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.
Yongyan TangState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.
Min HeState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.
Xuewei ChenState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.
Weitao LiState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, China.ORCID http://orcid.org/0000-0002-7843-5253

Funding

This study was supported by the National Natural Science Foundation of China (32121003 and 32425005) to X.C., (32172419 and 32372555) to W.L., (32472565) to X.Z., (32272560) to L.Z. and (32272033) to Y.T.; National Key Research and Development program (2021YFA1300702), Major Projects in Agricultural Biological Breeding (2022ZD04002), and New Cornerstone Science Foundation through the XPLORER PRIZE to X.C. National Key Research and Development Program of China for Young Scientists (2022YFD1401400) to X.Z.; College Student Innovation and Entrepreneurship Training Program Project (S202410626003) to Y.X.; Sichuan Science and Technology Program (2023NSFSC0005) to X.C., (2023NSFSC1996) to W.L., (2024YFNH0014) to J.Y., (2023NSFSC1937) to L.Z., (2024NSFSC1317) to Q.O., (2024NSFSC0322) to L.S., and (2022NSFSC0166) to Y.T.
6 · The paper itself

Abstract

The balance between the antagonistic traits, such as plant growth and disease resistance, is crucial for developing elite crop varieties. While the roles of plant hormones in this balance are well established, the regulatory function of secondary metabolites remains largely unexplored. Here, we report that 5-enolpyruvylshikimate-3-phosphate synthase (OsEPSPS), a key enzyme in the shikimate pathway, regulates both plant growth and disease resistance. Silencing the OsEPSPS gene in rice compromises the shikimate pathway but enhances the nicotinate and nicotinamide metabolism, resulting in the accumulations of trigonelline and nicotinamide mononucleotide (NMN). These metabolites boost resistance to rice blast by activating plant immune responses rather than inhibiting the germination and growth of Magnaporthe oryzae. Furthermore, silencing OsEPSPS conferring disease resistance results in less growth in plant. Our findings highlight the pivotal role of OsEPSPS in coordinating plant growth and disease resistance.

Indexed as

Disease ResistanceOryzaPlant DiseasesPlant ProteinsAlkaloidsAscomycotaGene Expression Regulation, PlantMagnaportheNiacinamideShikimic AcidAlkaloidsNiacinamidePlant ProteinsShikimic AcidtrigonellineEPSPSgrowthMagnaporthe oryzaenicotinamide mononucleotideresistanceshikimatetrigonelline

Identifiers

PMID40241284
PMCPMC13551649

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.