Evidence map›Paper›PMID 40241187›Full record

Observational studyLipids in health and disease2025

Hypothyroidism consequent to thyroidectomy is associated with elevated remnant lipoproteins and cholesterol enrichment of triglyceride-rich lipoproteins: an observational study.

Adrian Post, Mirthe H Links, Wouter T Zandee, Margery A Connelly, Thera P Links, Robin P F Dullaart

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adrian PostDepartment of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. a.post01@umcg.nl.
Mirthe H LinksDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Wouter T ZandeeDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Margery A ConnellyLabcorp, Morrisville, NC, USA.
Thera P LinksDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Robin P F DullaartDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypothyroidism may affect triglyceride-rich lipoprotein (TRL) subfractions and low-density lipoprotein (LDL) and their averaged sizes. The present study aimed to determine whether increases in remnant particles were larger than other TRL subfractions and whether changes in remnant particles were related to changes in the TRL cholesterol/triglyceride ratio.

methodsAn observational study was conducted to assess the impact of short term (4-6 weeks) hypothyroidism consequent to thyroidectomy on TRL subfractions, including remnant lipoproteins, LDL subfractions, and the TRL cholesterol and triglyceride content. Seventeen patients were studied: (1) during hypothyroidism, 4-6 weeks after total thyroidectomy for differentiated thyroid carcinoma (thyroid stimulating hormone (TSH) ranging from 59 to 371 mU/L) and free thyroxine (ranging from 0.8 to 6.8 pmol/L) and (2) after approximately 20 weeks of thyroid hormone supplementation, aimed at TSH levels below the reference range (TSH ranging from 0.01 to 2.15 mU/L). TRL, LDL subfractions, and the cholesterol and triglyceride content in TRL were measured by nuclear magnetic resonance spectroscopy.

resultsHypothyroidism led to substantial increases (> 30%, p < 0.001) in total cholesterol, LDL cholesterol, non-HighDensity Lipoproteins, triglycerides, TRL particle concentrations, and LDL particle concentrations. Among TRL subfractions, very small TRL particles (24-29 nm), corresponding to remnant lipoproteins, showed the most pronounced reduction (59%, 95% confidence interval (CI): 70-45%) after thyroid hormone supplementation (P < 0.001). TRL cholesterol content and the TRL cholesterol/triglyceride ratio were also higher during hypothyroidism (P < 0.001). Changes in TRL cholesterol correlated with changes in very small TRL particles (r = 0.70, 95% CI: 0.34-0.88, P = 0.002).

conclusionsProfound hypothyroidism confers increases in TRL and LDL particles, with the most pronounced effect on very small TRL (remnant) particles. These effects on remnants coincide with an increase in TRL cholesterol and the TRL cholesterol/triglyceride ratio. TRIAL REGISTRATION NUMBER: NTR ID 7228, 20-08-2018.

Indexed as

CholesterolHypothyroidismLipoproteinsThyroidectomyTriglyceridesAdultAgedCholesterol, LDLFemaleHumansLipoproteins, LDLMaleMiddle AgedThyroid NeoplasmsThyrotropinThyroxineCholesterolCholesterol, LDLLipoproteinsLipoproteins, LDLlipoprotein triglycerideThyrotropinThyroxineTriglyceridesHypothyroidismLipoproteins, LDLLipoproteins, VLDL nuclear magnetic resonance spectroscopyRemnant lipoproteins, thyroid stimulating hormoneThyroid neoplasms

Identifiers

PMID40241187
PMCPMC12001679

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.