ArticleGenome biology2025
Bayesian multi-study non-negative matrix factorization for mutational signatures.
Article in Genome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Robust discovery of mutational signatures using power posteriors.PLoS computational biology · 2026Article
- A Tutorial on Bayesian Multi-Study Factor Analysis With Applications in Nutrition and Genomics.Statistics in medicine · 2026Article
- Methodological Comparison of Short-Read and Long-Read Sequencing Methods on Colorectal Cancer Samples.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Mutational signatures are typically identified from tumor genome sequencing data using non-negative matrix factorization (NMF). However, existing NMF techniques only decompose a single dataset, limiting rigorous comparisons of signatures across conditions. We propose a Bayesian NMF method that jointly decomposes multiple datasets to identify signatures and their sharing pattern across conditions. We propose a fully unsupervised "discovery-only" model and a semi-supervised "recovery-discovery" model that simultaneously estimates known and novel signatures, and extend both to estimate covariate effects. We demonstrate our approach on extensive simulations, and apply our method to answer questions related to colorectal cancer and early-onset breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.