Trial reportJournal of neuroengineering and rehabilitation2025
Resting-state hemodynamic changes and effects on upper limb function after multi-channel transcranial direct current stimulation to the ipsilesional primary motor cortex and anterior intraparietal sulcus in stroke patients: an fNIRS pilot study.
Trial report in Journal of neuroengineering and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05275114 (Improvement Effect of Transcranial Direct Current Stimulation), which is not on this map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improvement Effect of Transcranial Direct Current Stimulation (tDCS) Applied During Exercise Training in Stroke Patients With Upper Limb and Hand Motor Function
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Completion rate and safety of non-invasive brain stimulation for upper limb dysfunction after stroke: a systematic review and network meta-analysis.Frontiers in neurology · 2026Pooled it
- Research hotspots and trends in electrical stimulation for movement disorders: a bibliometric analysis from 2016 to 2025.Frontiers in aging neuroscience · 2026Pooled it
- Functional near-infrared spectroscopy: Systematic mapping of abnormal brain function features in neurological disorders.Neural regeneration research · 2026Article
- Neuroplasticity After Stroke: Clinical Evidence and Its Implication for Effective Rehabilitation Strategies.Brain & NeuroRehabilitation · 2026Review
- [Research progress on the neuromodulation targets in stroke rehabilitation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Review
- Article
- Task-specific cortical mechanisms of taVNS-paired task-oriented training for post-stroke upper extremity dysfunction under cognitive load: an fNIRS study.Frontiers in human neuroscience · 2025Article
- Effects of cerebellar transcranial direct current stimulation on improving post-stroke upper extremity motor function: a protocol for a randomized controlled clinical trial.Frontiers in neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundStroke results in substantial long-term disability, necessitating effective recovery interventions. This study explored the effects of multi-channel transcranial direct current stimulation (tDCS) on hemodynamic responses and upper limb motor function in stroke patients, targeting the ipsilesional primary motor cortex (M1) and anterior intraparietal sulcus (aIPS).
methodsA double-blind, randomized, sham-controlled trial was conducted with 24 stroke patients (18 men; mean age, 57.3×14.2 years), who underwent 10 sessions of real or sham multi-channel tDCS combined with upper limb exercises. Functional near-infrared spectroscopy (fNIRS) measured resting-state cerebral hemodynamic responses for 5 min before and after each session. Motor function was evaluated using the Fugl-Meyer assessment for upper extremity (FMA-UE), box and block test (BBT), and other motor function tests before and after the interventions.
resultsThe real multi-channel tDCS group exhibited increases in regional accumulation of oxyhemoglobin (HbO
conclusionsMulti-channel tDCS targeting the ipsilesional M1 and aIPS, combined with upper limb exercises, showed potential effects on cerebral hemodynamics and motor function in stroke patients. These findings suggest that multi-channel tDCS may have a role in motor rehabilitation, but further research is needed to validate its efficacy and clinical applicability. CLINICALTRIALS: GOV: This study was registered at ClinicalTrials.gov (NCT05275114).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.