ArticleBMC veterinary research2025
Comparative analysis of reproductive organs, hormones and blood metabolism of MSTN mutated and non-mutated cows during gestation.
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- MSTNCells · 2026Article
- Targeting Myostatin for Sustainable Meat Production: Insights From Multiple Species.Animal genetics · 2026Review
- Clinical outcome of an SCNT-derivedFrontiers in genome editing · 2026Article
- MSTN gene editing does not alter reproductive capacity but modifies gestational metabolism in Mongolian cattle.BMC veterinary research · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundLong breeding cycle, long calving intervals and typical single calves limit the potential for improving their economic benefits. Ensuring the reproductive performance and efficiency of cows are crucial to increasing their economic value. Factors affecting the reproductive performance of cows include breed, pre-pregnancy maternal preparation, nutrition during pregnancy, and perinatal management. The gene editing of MSTN gene can improve the development of skeletal muscles and provide a new way for the promotion of existing beef cattle breeds. However, little has been reported about the reproductive performance and pregnancy state of MSTN gene-edited animals. In order to evaluate the reproductive safety and physiological changes during pregnancy of MSTN gene-edited cows, this study compared the sizes of reproductive organs, reproductive hormones, blood metabolic indicators, and metabolomic profiles at different stages of pregnancy, including period to be insemination, first trimester, second trimester, and late third trimester in MSTN gene-edited Luxi cattle (MT) and non-edited Luxi cattle (WT).
resultsThe results showed no significant differences in ovary and uterus sizes between MT and WT cows. However, MT cattle exhibited a larger pelvic area and higher calf birth weight. Compared to WT cattle, MT cattle showed enhanced glucose metabolism, reduced lipid synthesis, increased protein synthesis and absorption capacity, and decreased tryptophan synthesis at different stages of pregnancy. The hormone levels showed decreased E2 and increased P4 in MT cattle.
conclusionThe study demonstrates that MSTN gene editing has no significant impact on the reproductive safety of dairy cows and provides a deeper understanding of the feasibility of MSTN mutations for beef cattle breeding.
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