ArticleLipids in health and disease2025
Association between conicity index (C-index), relative fat mass (RFM), and osteoarthritis (OA): evidence from NHANES 2003-2018.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Targeting the FoxO-ferroptosis axis: mechanistic insights into Saikosaponin A-mediated protection against cartilage degeneration in osteoarthritis.Clinical rheumatology · 2026Article
- The joint association of health-enhancing walking and healthful diet with central obesity: a longitudinal repeated-measures study.International journal of obesity (2005) · 2026Article
- Unraveling 'F' factor: towards a genetic-clinical framework for the musculoskeletal-heart crosstalk in metabolic aging.Cardiovascular diabetology · 2026Article
- Association between conicity index and osteoporosis/femoral bone mineral density in USA adults : a cross-sectional study based on evidence from the National Health and Nutrition Examination Survey (2005 to 2020).Bone & joint research · 2026Article
- Association between low-density lipoprotein and structural changes in the knee joint of patients with symptomatic osteoarthritis is mediated by relative fat mass.European journal of medical research · 2026Article
- Evaluating anthropometric indices of obesity for early osteoarthritis detection: focus on body fat percentage and relative fat mass.Clinical rheumatology · 2025Article
- Constructing a Prognostic Model for Clear Cell Renal Cell Carcinoma Based on Glycosyltransferase Gene and Verification of Key Gene Identification.International journal of molecular sciences · 2025Article
- Comparative analysis of 16 baseline obesity and lipid-related indices for cardiovascular disease risk prediction in adults with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study.Diabetology & metabolic syndrome · 2025Article
- Association between relative fat mass and osteoarthritis in American adults.Frontiers in nutrition · 2025Article
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Abstract
backgroundObesity is considered an important risk factor for osteoarthritis (OA), with conicity index (C-index), relative fat mass (RFM) are two novel anthropometric measures of obesity. To investigate the association between OA and these two indicators, we conducted this study.
methodsWe used data from the National Health and Nutrition Examination Survey (NHANES) to investigate the association between C-index, RFM, and OA. First, the participants were divided into two groups according to whether they had OA, and we compared the baseline characteristics of the two groups. Then, C-index and RFM were divided into quartiles (Q1, Q2, Q3, Q4) for multivariate regression analysis. Additionally, we applied restricted cubic spline (RCS) to assess whether the relationship is non-linear. Finally, we conducted a subgroup interaction analysis to investigate whether this relationship varies across different subgroups.
resultsThe study included 34,707 participants, with a weighted OA prevalence of 7.7%. Significant differences in C-index and RFM were observed between OA and non-OA groups. Treating C-index and RFM as categorical variables, logistic regression showed significantly higher OA risk in Q4 compared to Q1: for C-index, Q4 (OR = 1.60; 95% CI: 1.33-1.93; P < 0.001); for RFM, Q4 (OR = 2.07; 95% CI: 1.57-2.73; P < 0.001). The RCS results show that the relationship between C-index and OA is non-linear, while the relationship between RFM and OA is linear. Subgroup interaction analysis showed some interaction effects.
conclusionsThis study reveals detailed relationships between C-index, RFM, and OA, which may be better indicators of obesity in assessing OA risk.
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