Evidence map›Paper›PMID 40240953›Full record

ArticleJournal of the American Heart Association2025

Real-World Clinical Impact of High-Sensitivity Troponin for Chest Pain Evaluation in the Emergency Department.

Jacob A Martin, Robert S Zhang, Aaron J Rhee, Archana Saxena, Olumide Akindutire, M Haisum Maqsood, Nicholas Genes, Nathan Gollogly, Nathaniel R Smilowitz, Adriana Quinones-Camacho

Abstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jacob A MartinDivision of Cardiovascular Medicine New York University New York NY.ORCID 0000-0003-3515-132X
Robert S ZhangDivision of Cardiology Weill Cornell Medicine New York NY.ORCID 0000-0002-7946-6094
Aaron J RheeDepartment of Medicine NYU Grossman School of Medicine New York NY.ORCID 0000-0002-3444-545X
Archana SaxenaDivision of Cardiovascular Medicine New York University New York NY.
Olumide AkindutireRonald O. Perelman Department of Emergency Medicine NYU Grossman School of Medicine New York NY.ORCID 0009-0007-0465-2670
M Haisum MaqsoodDepartment of Cardiology, DeBakey Heart and Vascular Center Houston Methodist Hospital Houston TX.ORCID 0000-0003-3907-4448
Nicholas GenesDepartment of Health Informatics NYU Grossman School of Medicine New York NY.ORCID 0000-0002-9836-2477
Nathan GolloglyDepartment of Health Informatics NYU Grossman School of Medicine New York NY.
Nathaniel R SmilowitzDivision of Cardiovascular Medicine New York University New York NY.ORCID 0000-0002-6823-2815
Adriana Quinones-CamachoDivision of Cardiovascular Medicine New York University New York NY.ORCID 0009-0003-2374-6403

Funding

Mechanisms of Coronary Microvascular DiseaseK23HL150315 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SMILOWITZ, NATHANIEL ROSSO · 2020 to 2024
$948k
NHLBI NIH HHS K23 HL150315
6 · The paper itself

Abstract

backgroundHigh-sensitivity cardiac troponin (hs-cTnI) assays can quantify troponin concentrations with low limits of detection, potentially expediting and enhancing myocardial infarction diagnoses. This study investigates the real-world impact of hs-cTnI implementation on operational metrics and downstream cardiac services in patients presenting to the emergency department with chest pain. METHODS AND

resultsWe conducted a retrospective study of patients who presented to 3 emergency departments for chest pain and in whom ≥1 troponin concentration was measured. We compared outcomes from January 2021 to March 2022 (conventional cardiac troponin I [cTnI]) against outcomes from April 2022 to March 2023 (post-hs-cTnI implementation). The primary outcome was hospital length of stay. The study included 32 076 emergency department patient-visits (17 267 with cTnI, 14 809 with hs-cTnI). Implementation of hs-cTnI was associated with shorter median total length of stay (6.6 versus 6.0 hours,

conclusionImplementation of the hs-cTnI assay was associated with reduced hospital admissions, shorter length of stay, and decreases in most downstream cardiac testing.

Indexed as

Chest PainEmergency Service, HospitalMyocardial InfarctionTroponin IAgedBiomarkersFemaleHumansLength of StayMaleMiddle AgedPredictive Value of TestsRetrospective StudiesBiomarkersTroponin Ichest painemergency departmenthigh‐sensitivitytroponin

Identifiers

PMID40240953
PMCPMC12184569

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.