Observational studyBMC pregnancy and childbirth2025
Risk of adverse obstetrical and neonatal outcomes in women consuming recreational drugs during pregnancy.
Observational study in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Review
- Temporal trend and influencing factors of high-risk pregnancy in China: a nationwide longitudinal analysis.Frontiers in public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreviously conducted studies have observed an increased risk of adverse maternal and neonatal outcomes with prenatal exposure to cocaine and opioids. However, these studies used drug-free reference groups which did not efficiently control for confounders associated with polysubstance use in pregnancy. Thus, we conducted an observational study to compare the risk of adverse obstetrical and neonatal outcomes in women who consumed cocaine and/or opioids during pregnancy to women who consumed only cannabis in pregnancy.
methodsThis observational study was conducted with data collected from pregnant women followed for addiction from the beginning of their pregnancy until childbirth at the perinatal consultation center Addi-Vie at CHUV Lausanne, Switzerland. Women who reported consuming cocaine, opioids, or both along with or without cannabis were included in the exposed group, while women who reported use of only cannabis during pregnancy were included in the reference group. We assessed for two adverse composite outcomes namely: adverse obstetrical composite outcome (4 outcomes) and adverse neonatal composite outcome (7 outcomes). Weighted logistic regression with weights obtained through inverse probability treatment weighting was conducted. For this analysis, we reported a conditional odds ratio (OR
resultsWe included 177 pregnant women in this study, with 80 included in the exposed group and 97 included in the reference group. In the exposed group, 81.2% of women reported the use of opioids, and 39.9% of women reported the use of cocaine during pregnancy. In this study, prenatal cocaine and/or opioid exposure was associated with reduced odds of adverse obstetrical composite outcomes (OR
conclusionPrenatal use of cocaine and/or opioids during pregnancy is observed to increase the odds of adverse neonatal composite outcomes. Encouraging substance users to seek antenatal care in earlier stages of pregnancy and targeted treatment approaches through interprofessional collaboration could prevent such adverse outcomes in pregnancy.
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