ArticleNature communications2025
Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis.
Abstract read
In one paragraph
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Extracellular vesicles from aged individuals trigger mitochondrial dysfunction in hematopoietic progenitor cells.Haematologica · 2026Article
- Aging of hematopoietic stem cells is inconsequential to progenitor cell function.Stem cell reports · 2026Article
- Clonal Hematopoiesis and Type 2 Diabetes: A Narrative Review.Journal of diabetes · 2026Review
- Transient MYC Mimicking the Exercise Response Orchestrates Multifaceted Skeletal Muscle Adaptations.bioRxiv : the preprint server for biology · 2026Article
- Ligature-induced periodontitis promotesHaematologica · 2026Article
- Mitochondrial drivers of stem cell aging and inflammaging.npj aging · 2026Review
- Re-evaluating the rationale for targeting oxidative phosphorylation in acute myeloid leukemia.The Biochemical journal · 2026Review
- Molecular and therapeutic frontiers in anemia therapy.The Journal of clinical investigation · 2026Review
- Anti-Apoptotic and Neurite-Protective Nanomedicine Augments Embryonic Stem Cells-Derived Retinal Ganglion Cell Transplantation in Glaucoma Recovery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Novel and emerging therapeutic strategies for clonal hematopoiesis.Haematologica · 2026Review
- Clonal Hematopoiesis in HIV and Atherosclerosis, Arterial Inflammation, and Lymph Node Metabolic Activity.medRxiv : the preprint server for health sciences · 2026Article
- Clonal hematopoiesis in the pathogenesis of non-hematologic diseases with therapeutic potential.Cancer cell international · 2026Review
- Metabolite-induced DNA damage drives stochastic stem cell loss and clonal hematopoiesis.Cell stem cell · 2026Article
- Multifunctional fluorescent carbon dots with synergistic-mechanism targeted mitochondria and Fe³⁺ detection.Mikrochimica acta · 2026Article
- Intrinsic and niche-dependent metabolic regulation of haematopoietic stem cells and implications for leukaemogenesis.Nature cell biology · 2026Review
- Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis.Cell chemical biology · 2026Article
- Article
- CHIP ahoy: charting a decade of discovery in clonal hematopoiesis.Haematologica · 2026Review
- Target practice: Opportunities for therapeutic intervention in CHIP and CCUS.Blood reviews · 2025Review
- Clonal Hematopoiesis and Cardiovascular Outcomes in Older Women.Journal of the American College of Cardiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Kira A YoungThe Jackson Laboratory, Bar Harbor, ME, USA.
Mohsen HosseiniPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-1686-8512
Jayna J MistryThe Jackson Laboratory, Bar Harbor, ME, USA.
Claudia MorgantiRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Departments of Cell Biology, Oncology and Medicine, Montefiore Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Taylor S MillsDivision of Hematology, Department of Immunology and Microbiology, Anschutz Medical Campus, University of Colorado, Aurora, CO, USA.
Xiurong CaiThe Jackson Laboratory, Bar Harbor, ME, USA.
Brandon T JamesThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID http://orcid.org/0000-0002-1824-747X
Griffin J NyeThe Jackson Laboratory, Bar Harbor, ME, USA.
Natalie R FournierThe Jackson Laboratory, Bar Harbor, ME, USA.
Veronique VoisinPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Ali CheginiPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0009-0007-8249-7258
Aaron D SchimmerPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-4023-3899
Gary D BaderPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-0185-8861
Grace EganPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-4036-8403
Marc R MansourUCL Cancer Institute, Department of Developmental Biology and Cancer, UCL Great Ormond Street Institute of Child Health, London, UK.ORCID http://orcid.org/0000-0001-6835-3791
Grant A ChallenDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-4669-8814
Eric M PietrasDivision of Hematology, Department of Immunology and Microbiology, Anschutz Medical Campus, University of Colorado, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-7339-8828
Kelsey H Fisher-WellmanEast Carolina University, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, Department of Physiology, Greenville, NC, USA.
Keisuke ItoRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Departments of Cell Biology, Oncology and Medicine, Montefiore Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0002-6702-9735
Steven M ChanPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-4354-0731
Jennifer J TrowbridgeThe Jackson Laboratory, Bar Harbor, ME, USA. Jennifer.trowbridge@jax.org.ORCID http://orcid.org/0000-0002-7636-9504
Funding
Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9MThe Roles of Lipid Metabolism in the Maintenance of Hematopoietic Stem CellsR01DK098263 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Keisuke Ito · 2013 to 2026
$5.2MDissecting the canonical and non-canonical functions of Tet2 in hematopoietic stem cells and hematologic disordersR01HL148852 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Meelad Dawlaty, Keisuke Ito · 2019 to 2026
$4.4MDeveloping Effective Approaches to Extend Hematopoietic Healthspan by Targeting Cell-Extrinsic and Cell-Intrinsic Alterations at Middle AgeR01DK118072 · NIDDK · JACKSON LABORATORY · PI Jennifer Jean Trowbridge · 2018 to 2026
$4.2MInflammatory Signaling in DNMT3A-Mutated Human Hematopoietic Stem CellsU01AG077925 · NIA · JACKSON LABORATORY · PI LEVINE, ROSS L, TROWBRIDGE, JENNIFER JEAN · 2021 to 2025
$2.9MInflammatory Stress Promotes Clonal Expansion of DNMT3A-mutant HSCsR01DK124883 · NIDDK · WASHINGTON UNIVERSITY · PI Grant Anthony Challen · 2020 to 2026
$2.5MDiscovery of Aging-Associated Mechanisms Causing Expansion and Progression of Clonal Hematopoiesis of Indeterminant Potential (CHIP)R01AG069010 · NIA · JACKSON LABORATORY · PI TROWBRIDGE, JENNIFER JEAN · 2020 to 2024
$2.4MImpact of IL-1 signaling on hematopoietic stem cell function and emergence of clonal hematopoiesis.R01DK119394 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI PIETRAS, ERIC M · 2019 to 2023
$2.0MAberrant glycolysis as a driver of mutant HSPC expansion in clonal hematopoiesisR01DK137183 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Eric M Pietras · 2023 to 2026
$1.8M120kV Transmission Electron Microscope for a Multi-user Microscopy FacilityS10OD016214 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CONDEELIS, JOHN S · 2014 to 2014
$459kDeveloping Effective Approaches to Extend Hematopoietic Healthspan by Targeting Cell-Extrinsic and Cell-Intrinsic Alterations at Middle AgeR56DK118072 · NIDDK · JACKSON LABORATORY · PI TROWBRIDGE, JENNIFER JEAN · 2023 to 2023
$100kNCI NIH HHS P30 CA034196NHLBI NIH HHS R01 HL148852NIA NIH HHS R01 AG069010NIA NIH HHS U01 AG077925NIDDK NIH HHS R01 DK098263NIDDK NIH HHS R01 DK118072NIDDK NIH HHS R01 DK119394NIDDK NIH HHS R01 DK124883NIDDK NIH HHS R01 DK137183NIDDK NIH HHS R56 DK118072NIH HHS S10 OD016214U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P30CA034196U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL148852U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK098263U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK118072U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK119394U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK124883U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R56DK118072U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG069010U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) U01AG077925
Abstract
The competitive advantage of mutant hematopoietic stem and progenitor cells (HSPCs) underlies clonal hematopoiesis (CH). Drivers of CH include aging and inflammation; however, how CH-mutant cells gain a selective advantage in these contexts is an unresolved question. Using a murine model of CH (Dnmt3a
Indexed as
Clonal HematopoiesisDNA (Cytosine-5-)-MethyltransferasesHematopoietic Stem CellsMembrane Potential, MitochondrialAgingAnimalsApoptosisDNA MethylationDNA Methyltransferase 3AHematopoiesisHumansMaleMiceMice, Inbred C57BLMitochondriaMutationDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanDnmt3a protein, mouseOrganophosphorus Compounds
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.