Evidence map›Paper›PMID 40240720›Full record

ArticleAIDS and behavior2025

Quality of Life among Predominately African Americans with HIV Who Use Drugs: The Role of Patient-Provider Engagement in Mediating the Impacts of Depression and Healthcare Discrimination.

Tuo-Yen Tseng, Mary M Mitchell, Geetanjali Chander, Carl Latkin, Caitlin Kennedy, S Ian Borison, Chaeyeon Son, Amy R Knowlton

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Article in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tuo-Yen TsengJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. tuoyen@jhu.edu.ORCID http://orcid.org/0000-0002-5634-3374
Mary M MitchellPennsylvania State University, University Park, PA, USA.
Geetanjali ChanderUniversity of Washington School of Medicine, Seattle, WA, USA.
Carl LatkinJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Caitlin KennedyJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
S Ian BorisonJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Chaeyeon SonJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Amy R KnowltonJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Funding

Sustaining palliative care to drug users with HIV/AIDS & health disparitiesR01NR014050 · NINR · JOHNS HOPKINS UNIVERSITY · PI KNOWLTON, AMY · 2013 to 2017
$2.3M
Informal Caregiving & Medical Adherence Among HIV+ IDUsR01DA019413 · NIDA · JOHNS HOPKINS UNIVERSITY · PI KNOWLTON, AMY · 2006 to 2009
$2.2M
Mentoring and Patient Oriented Research at the Nexus of Unhealthy Alcohol Use and HIVK24AA027483 · NIAAA · UNIVERSITY OF WASHINGTON · PI GEETANJALI CHANDER · 2019 to 2026
$1.3M
Foundation for the National Institutes of Health 1P30 AI094189NIAAA NIH HHS K24 AA027483NIDA NIH HHS R01 DA019413NINR NIH HHS R01 NR014050
6 · The paper itself

Abstract

Enhancing mental health-related quality of life (MHRQOL) is an important clinical objective for people with HIV (PWH), due to their elevated risk of psychological distress and mental health challenges. Depression, pain, stigma, and discrimination are among the main contributors to poor MHRQOL in this population and can negatively impact PWH's interaction with their healthcare providers, and vice versa. We used structural equation modeling to examine whether the quality of patient-provider engagement in HIV primary care mediated the effects of depression and prior experiences of discrimination in healthcare settings on later MHRQOL, assessed using the SF- 12 Mental Component Summary (MCS- 12), among a sample of predominately African Americans with HIV and a history of drug use. A total of 331 participants, recruited from HIV clinics and community venues in Baltimore, Maryland, USA, completed three semi-annual surveys between 2014 and 2018. At baseline, the sample showed a high percentage of probable depression (35.6%) and a low MCS- 12 mean score (38.72, SD = 6.88) compared with the US general population norm of 50 (SD = 10). There were significant indirect paths from baseline depression (β = - 0.04, 95% CI = - 0.10, - 0.01) and healthcare discrimination (β = - 0.05, 95% CI = - 0.12, - 0.01) to lower MHRQOL at 12-months, mediated through reduced patient-centered patient-provider engagement with primary care providers at 6-months, after adjusting for baseline assessment of the mediator and the outcome, demographic covariates, substance use, pain level, and time since HIV diagnosis. Findings suggest a potential for mitigating the impacts of depression and healthcare discrimination on MHRQOL through intervening on the quality of patient-provider engagement.

Indexed as

Black or African AmericanDepressionHIV InfectionsQuality of LifeSubstance-Related DisordersAdultBaltimoreFemaleHumansMaleMiddle AgedPrimary Health CareSocial StigmaSurveys and QuestionnairesWhiteDiscriminationHIV/AIDSInterpersonal communicationMental health-related quality of lifePatient-provider engagementSubstance use

Identifiers

PMID40240720

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.