Evidence map›Paper›PMID 40240629›Full record

ArticleAnalytical and bioanalytical chemistry2025

A sensitive method for simultaneous screening exposure to 14 alkylating agents based on tripeptide adducts: an efficient approach for chemical weapon verification and chemical impurity profiling in plasma samples.

Bo Chen, Deshen Liang, Huilan Yu, Changcai Liu, Ling Yuan, Fengyun Wang, Shilei Liu

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bo Chen *State Key Laboratory of NBC Protection for Civilian, Beijing, 102205, P. R. China.
Deshen Liang *School of Chemistry and Chemical Engineering, Nanjing University of Science & Technology, Nanjing, 210094, P. R. China.
Huilan YuState Key Laboratory of NBC Protection for Civilian, Beijing, 102205, P. R. China.
Changcai LiuState Key Laboratory of NBC Protection for Civilian, Beijing, 102205, P. R. China.
Ling YuanState Key Laboratory of NBC Protection for Civilian, Beijing, 102205, P. R. China.
Fengyun WangSchool of Chemistry and Chemical Engineering, Nanjing University of Science & Technology, Nanjing, 210094, P. R. China. wangfy@njust.edu.cn.
Shilei LiuState Key Laboratory of NBC Protection for Civilian, Beijing, 102205, P. R. China. liu_shilei@lacricd.com.

Funding

State Key Laboratory of NBC Protection for Civilian SKLNBC2021-04
6 · The paper itself

Abstract

For the implementation of the Chemical Weapons Convention, the Organisation for Prohibition of Chemical Weapons (OPCW) designates laboratories for the analysis of chemicals that can be used as chemical warfare agents (CWAs). In these laboratories, analytical methods for detecting CWAs have been developed for environmental and biomedical samples. Protein adducts from exposed biomedical samples are an important type of biomarker for verification of their abuse. Moreover, these adducts could also be applied in chemical impurity profiling studies of biomedical samples. Alkylating agents, as cytotoxicants, can react with Cys

Indexed as

Alkylating AgentsChemical Warfare AgentsOligopeptidesBiomarkersChromatography, High Pressure LiquidHumansLimit of DetectionTandem Mass SpectrometryAlkylating AgentsBiomarkersChemical Warfare AgentsOligopeptidesAlkylating agentBiomarkerChemical impurity profilingNitrogen mustardsSulfur mustardsTripeptide adduct

Identifiers

PMID40240629

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.