ArticleLangenbeck's archives of surgery2025
Transversalis fascia collagen content and the risk of surgical complications: results of a prospective study.
Article in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Metabolism, Morphology and Function of the Anterior Abdominal Wall Musculature in Ventral Hernias and After Repair: A Narrative Review and Research Agenda.Journal of personalized medicine · 2026Review
- Incidence and risk factors for incisional hernia after partial liver resection via an inverted L-incision: a retrospective single-centre cohort study.BMC surgery · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundCollagen is the major protein of the extracellular matrix that provides mechanical strength to the tissues. The relationship between the development of complications and the quality and quantity of collagen fibres has not been investigated in the literature, yet.
methodsThis was a prospective study of 392 patients who underwent subcostal laparotomy for confirmed or suspected gastrointestinal malignancy. Prior to abdominal closure a sample of transversalis fascia was collected. The area covered by collagen (ACC) was measured as the mean area covered by Picosirius stained fibres in three areas of the fascia. The primary endpoint of the study was the occurrence of complications, graded according to the Clavien-Dindo over a 90-day follow-up period.
results392 patients were included in the study. A transversalis fascia sample was obtained in 354 patients (90.3%) and image assessment yielded a group of 259 specimens that were included in the analysis (66.1%). Predicting the development of complications of at least CD III based on ACC was associated with an AUC of 0.606 (p = 0.027) and an optimal threshold of 0.771. There were significantly fewer complications of at least CD III in the group of patients with ACC ≥ 0.771 (6/125) than in the group below the threshold (25/134) (p < 0.01).
conclusionsCollagen content may serve as an adjunct predictor of surgical risk, although its clinical utility requires further validation. There is a need for further studies on the causal nature of this relationship and modifiable risk factors related to body collagen quality.
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