ArticleNature2025
Metformin reduces the competitive advantage of Dnmt3a
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed.
- Metformin Downregulates the STAT Pathway and Reduces Bone Marrow Fibrosis in Primary Myelofibrosis Patients: Final Results of the Phase II FIBROMET Trial.Hematological oncology · 2026Trial
- Clonal hematopoiesis-associated DNMT3A mutations derepress bivalent Polycomb target genes and enhance macrophage migration.bioRxiv : the preprint server for biology · 2026Article
- Impaired Glycolysis Leads to Defective Efferocytosis and Impaired Plaque Resolution inCirculation · 2026Article
- Extracellular vesicles from aged individuals trigger mitochondrial dysfunction in hematopoietic progenitor cells.Haematologica · 2026Article
- Exacerbation of inflammatory bone loss in TET2-driven clonal hematopoiesis.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Elevated mitochondrial protein import in acute myeloid leukemia increases reliance on mitochondrial protease LONP1.The Journal of clinical investigation · 2026Article
- Targeting UXS1-Dependent Glucuronate Detoxification Potentiates Metformin's Anti-Tumor Efficacy in Lung Adenocarcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Specific FbioRxiv : the preprint server for biology · 2026Article
- Clonal Hematopoiesis and Type 2 Diabetes: A Narrative Review.Journal of diabetes · 2026Review
- Ligature-induced periodontitis promotesHaematologica · 2026Article
- Metabolic Crosstalk Between Host and Tumor as a Circuit of Resilience in Cancer Therapy.Cells · 2026Review
- Clonal haematopoiesis and cardiovascular disease, defining risk, filling gaps, and framing the future.NPJ cardiovascular health · 2026Review
- Clonal hematopoiesis in patients with cancer and cancer survivors: From clonal burden to cardiovascular diseases.Cancer · 2026Review
- CHIP clinics: a practical overview of structure and function.Blood cancer journal · 2026Review
- Phytocannabinoids as epigenetic regulators: bridging DNA methylation and redox homeostasis in glioblastoma.Journal of applied genetics · 2026Article
- Clinical decisions in clonal hematopoiesis: a contemporary review for clinicians.Haematologica · 2026Review
- Clonal hematopoiesis and its progression to myeloid neoplasms: insights into risk, biology, and therapeutic strategies.Haematologica · 2026Review
- Novel and emerging therapeutic strategies for clonal hematopoiesis.Haematologica · 2026Review
- Inflammageing and clonal haematopoiesis interplay and their impact on human disease.Nature reviews. Molecular cell biology · 2026Review
- Targeting microglial PANoptosis through AMPK activation: Metformin as a promising therapy for spinal cord injury.Journal of pharmaceutical analysis · 2026Article
Corrections and comments
- Update of
Authors and funding
27 authors.
Mohsen HosseiniPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID 0000-0002-1686-8512
Veronique Voisin *Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada.ORCID 0000-0002-3405-9532
Ali Chegini *Princess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID 0009-0007-8249-7258
Angelica Varesi *Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Severine Cathelin *Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Dhanoop Manikoth AyyathanPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Alex C H LiuPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Yitong YangPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Vivian WangPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Abdula MaherPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID 0009-0009-6535-6888
Eric GrignanoPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Julie A ReiszDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-2258-6490
Kira YoungThe Jackson Laboratory, Bar Harbor, ME, USA.
Yiyan WuDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Martina FiumaraSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0009-0007-5934-9273
Samuele FerrariSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0003-1122-1231
Luigi NaldiniSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-7835-527X
Federico GaitiPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID 0000-0001-5111-8816
Shraddha PaiDonnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada.
Grace EganPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID 0000-0002-4036-8403
Aaron D SchimmerPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID 0000-0003-4023-3899
Gary D BaderDonnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada.
John E DickPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Stephanie Z XiePrincess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID 0000-0002-0284-494X
Jennifer J TrowbridgeThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-7636-9504
Steven M ChanPrincess Margaret Cancer Centre, Toronto, Ontario, Canada. steven.chan@uhn.ca.ORCID 0000-0002-4354-0731
Funding
University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0MNCI NIH HHS P30 CA046934University of Toronto, a New Investigator Award from the Leukemia Research Foundation
Abstract
Clonal haematopoiesis arises when a haematopoietic stem cell (HSC) acquires a mutation that confers a competitive advantage over wild-type HSCs, resulting in its clonal expansion. Individuals with clonal haematopoiesis are at increased risk of developing haematologic neoplasms and other age-related inflammatory illnesses
Indexed as
Cell CompetitionClonal HematopoiesisDNA (Cytosine-5-)-MethyltransferasesHematopoietic Stem CellsMetforminAnimalsCell RespirationClone CellsDNA MethylationDNA Methyltransferase 3AFemaleHistonesHumansMaleMiceMitochondriaDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanDnmt3a protein, mouseHistonesMetformin
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.