Evidence map›Paper›PMID 40240459›Full record

ArticleScientific reports2025

Vibrational circular dichroism of plasmonic nanostructures embedding chiral drugs.

Raju Adhikary, Matteo Venturi, Giovanna Salvitti, Ambaresh Sahoo, Carino Ferrante, Paola Benassi, Francesco Di Stasio, Andrea Toma, Hatice Altug, Massimiliano Aschi and 1 more

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Raju AdhikaryDepartment of Physical and Chemical Sciences, University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy.
Matteo VenturiDepartment of Physical and Chemical Sciences, University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy.
Giovanna SalvittiDepartment of Physical and Chemical Sciences, University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy.
Ambaresh SahooDepartment of Physical and Chemical Sciences, University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy.
Carino FerranteCNR-SPIN, c/o Dip.to di Scienze Fisiche e Chimiche, Via Vetoio, Coppito (L'Aquila), 67100, Italy.
Paola BenassiDepartment of Physical and Chemical Sciences, University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy.
Francesco Di StasioIstituto Italiano di Tecnologia, Via Morego 30, Genova, 16136, Italy.
Andrea TomaIstituto Italiano di Tecnologia, Via Morego 30, Genova, 16136, Italy.
Hatice AltugInstitute of Bioengineering, École polytechnique fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland.
Massimiliano AschiDepartment of Physical and Chemical Sciences, University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy.
Andrea MariniDepartment of Physical and Chemical Sciences, University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy. andrea.marini@univaq.it.

Funding

European Union - NextGenerationEU under the Italian Ministry of University and Research (MUR) National Innovation Ecosystem grant ECS00000041 - VITALITY - CUP E13C22001060006HORIZON EUROPE European Innovation Council 101046424
6 · The paper itself

Abstract

We investigate the mid-infrared chiroptical response of plasmonic nanostructures based on Al-doped ZnO and layers of an aqueous solution of Ladarixin, a chiral pharmaceutical currently under clinical trial for the treatment of type 1 diabetes. We explore the possibilities offered by localised surface plasmon resonances (LSPRs) for the enhancement of vibrational circular dichroism (VCD) of the considered chiral drug solution. Focusing on diverse plasmonic nanoshell geometries, we find that LSPRs provide an amplification factor of VCD differential absorption cross-section ranging from [Formula: see text] to [Formula: see text] thanks to near-field intensity enhancement produced by LSPRs. Our results indicate that nanoshell LSPRs are promising for probing molecular chirality at the nanoscale.

Identifiers

PMID40240459
PMCPMC12003888

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.