Evidence map›Paper›PMID 40240451›Full record

ArticleScientific reports2025

Understanding preservation time thresholds in the modern era of heart transplantation.

Chen Chia Wang, Jessica B Briscoe, Corbin E Goerlich, Rachael Quinn, Daniel Ragheb, Shivani Shirodkar, Antonio Polanco, Ahmet Kilic, Kavita Sharma, James Gammie and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Revealing the potential of non-transplanted donor organs: a comparative analysis in the Eurotransplant region.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chen Chia WangVanderbilt University School of Medicine, Nashville, MD, USA.
Jessica B BriscoeDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, 1800 Orleans St Zayed 7, Baltimore, MD, 21287, USA.
Corbin E GoerlichDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, 1800 Orleans St Zayed 7, Baltimore, MD, 21287, USA.
Rachael QuinnDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, 1800 Orleans St Zayed 7, Baltimore, MD, 21287, USA.
Daniel RaghebVanderbilt University School of Medicine, Nashville, MD, USA.
Shivani ShirodkarDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, 1800 Orleans St Zayed 7, Baltimore, MD, 21287, USA.
Antonio PolancoDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, 1800 Orleans St Zayed 7, Baltimore, MD, 21287, USA.
Ahmet KilicDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, 1800 Orleans St Zayed 7, Baltimore, MD, 21287, USA.
Kavita SharmaDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
James GammieDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, 1800 Orleans St Zayed 7, Baltimore, MD, 21287, USA.
Ashish S ShahDivision of Cardiac Surgery, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Chetan PasrijaDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, 1800 Orleans St Zayed 7, Baltimore, MD, 21287, USA. cpasrij1@jh.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 4-h preservation time threshold for cardiac allografts is the current standard in heart transplantation, but novel technologies are proposed to decrease the morbidity associated with prolonged allograft storage. This study examined adult heart transplant recipients from 2000-2015 and 2020-2023 in the United States, stratified into an early (2000-2015) and modern era (2020-2023), then into standard (≤ 4 h) and prolonged (≥ 5 h) preservation time groups within each era. This study reinforced the 4-h threshold in the early era, where prolonged preservation significantly increased one-year mortality (HR 1.60, 95% CI 1.36-1.90). However, this association was no longer significant in the modern era (HR 1.14, 95% CI 0.85-1.50). A sub-analysis showed that using machine perfusion devices for allograft storage was not associated with one-year mortality (HR 1.15, 95% CI 0.79-1.70). Spline analysis demonstrated possible inflection points between 4 and 5 h and 8-9 h in the modern era, and further analysis found that 5-8 h of preservation did not increase one-year mortality (HR 1.09, 95% CI 0.80-1.47) relative to the ≤ 4 h group. In conclusion, the association between cardiac allograft preservation duration and morbidity has decreased in the modern era. Today, a 4-h preservation duration threshold may be too restrictive.

Indexed as

Heart TransplantationOrgan PreservationAdultAgedAllograftsFemaleHumansMaleMiddle AgedTime FactorsUnited StatesDonor allocation policyHeart transplantMachine perfusionOne-year survivalOrgan preservationStatic cold storage

Identifiers

PMID40240451
PMCPMC12003707

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.