Evidence map›Paper›PMID 40240397›Full record

ArticleScientific reports2025

Clinical and genetic analysis of oral and nasal staphylococcus aureus isolates in dental patients.

Tomoki Kawayanagi, Miki Kawada-Matsuo, Satoru Kusaka, Yoshimasa Yasutomi, Yujin Suzuki, Saki Nishihama, Mi Nguyen-Tra Le, Yo Sugawara, Junzo Hisatsune, Shoko Kutsuno and 6 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Dental Consultation in Initially Unknown-SourceAntibiotics (Basel, Switzerland) · 2026
    Article
  4. Methicillin-resistantiScience · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tomoki KawayanagiDepartment of Biological Endodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Miki Kawada-MatsuoDepartment of Bacteriology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Hiroshima City, 734-8551, Hiroshima, Japan. mmatsuo@hiroshima-u.ac.jp.
Satoru KusakaDepartment of Bacteriology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Hiroshima City, 734-8551, Hiroshima, Japan.
Yoshimasa YasutomiDepartment of Bacteriology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Hiroshima City, 734-8551, Hiroshima, Japan.
Yujin SuzukiDepartment of Bacteriology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Hiroshima City, 734-8551, Hiroshima, Japan.
Saki NishihamaDepartment of Biological Endodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Mi Nguyen-Tra LeDepartment of Bacteriology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Hiroshima City, 734-8551, Hiroshima, Japan.
Yo SugawaraAntimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Junzo HisatsuneProject Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima, Japan.
Shoko KutsunoAntimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Mikari AsakawaSection of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Toru TakeshitaSection of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Ryota NomuraDepartment of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Hideki ShibaDepartment of Biological Endodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Motoyuki SugaiProject Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima, Japan.
Hitoshi KomatsuzawaDepartment of Bacteriology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Hiroshima City, 734-8551, Hiroshima, Japan. komatsuz@hiroshima-u.ac.jp.

Funding

The Japan Agency for Medical Research and Development (AMED) JP23fk0108606
6 · The paper itself

Abstract

Staphylococcus aureus is a common bacterium that sometimes causes various pyogenic diseases. Methicillin resistant S. aureus (MRSA) infections are particularly difficult to treat. Recently, MRSA has been spreading in the community, so it is important to determine the prevalence of MRSA in the community and to conduct epidemiological studies from genetic and statistical perspectives. In this study, S. aureus/MRSA was isolated from the oral and nasal cavities of 504 dental patients (65 inpatients and 439 outpatients). Sixty-two S. aureus strains and 9 MRSA strains were isolated from the oral cavity, and 112 S. aureus strains and 21 MRSA strains were isolated from the nasal cavity. Multi-locus sequence typing (MLST) analysis showed ST8 was high (18 isolates) among 30 MRSA isolates, whereas among 144 methicillin sensitive isolates, ST15 (25 isolates) and ST8 (20 isolates) were high. Statistical analysis of the patients' clinical status revealed a correlation between oral S. aureus and denture use. Among the 34 patients from whom S. aureus was isolated from both sites, 25 had the same ST, and 23 showed below 40 single-nucleotide polymorphisms which are considered to be identical strains. Our study revealed various properties of S. aureus/MRSA in the oral and nasal cavities as commensals.

Indexed as

Methicillin-Resistant Staphylococcus aureusMouthNasal CavityStaphylococcal InfectionsStaphylococcus aureusAdolescentAdultAgedFemaleHumansMaleMiddle AgedMultilocus Sequence TypingPolymorphism, Single NucleotideYoung Adult

Identifiers

PMID40240397
PMCPMC12003906

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.