Evidence map›Paper›PMID 40240348›Full record

ArticleBlood cancer journal2025

PDL1-expressing macrophages infiltrate diffuse large B-cell lymphoma and promote lymphoma growth in a MYC-driven experimental model.

Ningxuan Cui, Peter Leary, Vanesa-Sindi Ivanova, Kristin Stirm, Lydia Kirsche, Nicola Aceto, Frank Stenner, Lothar C Dieterich, Michael Detmar, Ekaterina Petrova and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood cancer journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ningxuan CuiInstitute of Molecular Cancer Research, University of Zürich, Zürich, Switzerland.
Peter LearyInstitute of Molecular Cancer Research, University of Zürich, Zürich, Switzerland.
Vanesa-Sindi IvanovaInstitute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Kristin StirmInstitute of Molecular Cancer Research, University of Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-8870-164X
Lydia KirscheInstitute of Molecular Cancer Research, University of Zürich, Zürich, Switzerland.ORCID http://orcid.org/0009-0002-1826-3952
Nicola AcetoInstitute of Molecular Health Sciences, Swiss Federal Institute of Technology Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0001-9579-6918
Frank StennerClinic for Medical Oncology, University Hospital Basel, Basel, Switzerland.
Lothar C DieterichEuropean Center for Angioscience and Mannheim Institute of Innate Immunoscience, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-7908-5710
Michael DetmarInstitute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zürich, Zürich, Switzerland.
Ekaterina PetrovaInstitute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Sarah MundtInstitute of Experimental Immunology, University of Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0003-2169-2109
Melanie GreterInstitute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Alexandar TzankovInstitute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-1100-3819
Anne MüllerInstitute of Molecular Cancer Research, University of Zürich, Zürich, Switzerland. mueller@imcr.uzh.ch.ORCID http://orcid.org/0000-0002-1368-8276

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The infiltration of diffuse large- and other mature B-cell lymphomas with T- and myeloid cells is a key tumor microenvironmental feature but is not currently factored into treatment decisions. Here, we have used multiplex immunofluorescence microscopy to quantify the immune infiltrates of >260 diffuse large B-cell- (DLBCL), follicular- (FL) and mantle cell lymphomas (MCL), and chronic lymphocytic leukemias (CLL) relative to clinical outcomes, mutational landscape and phenotype. MCL were found to be the "coldest" and DLBCL the "hottest" entities. The lymphoma microenvironment of DLBCL featured numerically dominant populations of CD8

Indexed as

B7-H1 AntigenLymphoma, Large B-Cell, DiffuseMacrophagesProto-Oncogene Proteins c-mycAnimalsDisease Models, AnimalHumansMiceTumor MicroenvironmentB7-H1 AntigenCD274 protein, humanProto-Oncogene Proteins c-myc

Identifiers

PMID40240348
PMCPMC12003652

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.