Evidence map›Paper›PMID 40240291›Full record

ArticleAging2025

Frailty predicts adverse clinical outcomes in patients with moderate to severe chronic kidney disease.

Chiung-Ying Huang, Hsiao-Mei Tsao, Shu-Ling Liang, Tai-Shuan Lai, Yung-Ming Chen

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Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Chiung-Ying HuangDepartment of Medicine, National Taiwan University Hospital, Bei-Hu Branch, Taipei, Taiwan.
Hsiao-Mei TsaoDepartment of Internal Medicine, Division of Nephrology, National Taiwan University Hospital, Taipei, Taiwan.
Shu-Ling LiangDepartment of Internal Medicine, Division of Nephrology, National Taiwan University Hospital, Taipei, Taiwan.
Tai-Shuan LaiDepartment of Internal Medicine, Division of Nephrology, National Taiwan University Hospital, Taipei, Taiwan.
Yung-Ming ChenDepartment of Medicine, National Taiwan University Hospital, Bei-Hu Branch, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimFrailty predicts adverse clinical outcomes in older adults. Its prognoses in individuals with specific illnesses have not been fully explored. This study aimed to investigate the impact of frailty by using a semiautomated instrument in patients with advanced chronic kidney disease (CKD). METHODS AND

resultsIn this prospective study, patients with CKD3b-5 before dialysis and aged ≥55 years with a clinical frailty scale of ≤5 were enrolled. Frailty was assessed by three commonly-used evaluation tools, i.e., Fried's frailty phenotype, Study of Osteoporotic Fractures (SOF) index, and Frailty index of 80 risk variables (FI80) incorporated in a semiautomated platform. Logistic regression, Kaplan-Meier analysis, and Cox proportional hazards models were used to analyze the predictors for frailty and the impact of frailty on composite outcomes of dialysis and overall death. Among 315 patients, the mean age was 73.1 years, and the estimated glomerular filtration rate was 22.2 ml/min/1.73 m

conclusionsFrailty is common among CKD patients, and its prevalence increases with age and disease advancement. The frailty status identified by the FI80 effectively predicted end-stage kidney disease or death in patients with advanced CKD.

Indexed as

FrailtyRenal Insufficiency, ChronicAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisProspective StudiesRenal DialysisRisk FactorsSeverity of Illness Indexchronic kidney diseasefrailtyfrailty indexFried’s frailty phenotypeSOF index

Identifiers

PMID40240291
PMCPMC12074821

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.