Evidence map›Paper›PMID 40240290›Full record

ReviewFEMS microbiology reviews2025

Role of the LuxR solo, SdiA, in eavesdropping on foreign bacteria.

Andrew Schwieters, Brian M M Ahmer

Abstract readReview
In one paragraph

Review in FEMS microbiology reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Frontiers in microbiology · 2026
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andrew SchwietersDepartment of Microbiology, The Ohio State University, Columbus, OH 43210, United States.ORCID 0000-0003-3594-8128
Brian M M AhmerDepartment of Microbiology, The Ohio State University, Columbus, OH 43210, United States.ORCID 0000-0002-4267-7322

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
Microbial ecology of the inflamed intestineR01AI143288 · NIAID · OHIO STATE UNIVERSITY · PI AHMER, BRIAN M, WRIGHTON, KELLY C · 2018 to 2022
$3.5M
Salmonella-specific therapeuticsR01AI140541 · NIAID · OHIO STATE UNIVERSITY · PI AHMER, BRIAN M, GOPALAN, VENKAT · 2018 to 2021
$2.8M
Salmonella, colonization resistance, and fructose-asparagineR01AI116119 · NIAID · OHIO STATE UNIVERSITY · PI AHMER, BRIAN M, BEHRMAN, EDWARD J. · 2015 to 2019
$2.5M
NCI NIH HHS P30 CA016058NIAID NIH HHS R01 AI116119NIAID NIH HHS R01 AI140541NIAID NIH HHS R01 AI143288
6 · The paper itself

Abstract

Bacteria can cooperate by coordinating their gene expression through the production, release, and detection of small molecules, a phenomenon known as quorum sensing (QS). One type of QS commonly found in Gram-negative bacteria utilizes a LuxI-type enzyme to produce a signaling molecule of the N-acyl-homoserine lactone (AHL) family, and a transcription factor of the LuxR family to detect and respond to the AHL. In a subset of Enterobacteriaceae, including Escherichia coli and Salmonella, no LuxI family member is present and no AHLs are synthesized. However, they encode a LuxR family member, SdiA, that is used to detect the QS molecules of other bacterial species, a behavior known as eavesdropping. Despite significant research on the topic, the overall role of SdiA-mediated eavesdropping in these bacteria remains unclear. In this review, we discuss the phenotypes and regulons of SdiA in the Enterobacteriaceae.

Indexed as

Bacterial ProteinsEnterobacteriaceaeQuorum SensingRepressor ProteinsTrans-ActivatorsAcyl-ButyrolactonesGene Expression Regulation, BacterialAcyl-ButyrolactonesBacterial ProteinsLuxR autoinducer binding proteinsRepressor ProteinsSdiA protein, bacteriaTrans-Activatorsacyl homoserine lactoneseavesdroppingE. coliquorum sensingSalmonellaSdiA

Identifiers

PMID40240290
PMCPMC12086679

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.