Evidence map›Paper›PMID 40240157›Full record

ArticleEnvironmental health and preventive medicine2025

Association between maternal distress during pregnancy and lower 5-min-Apgar score of the offspring: the Japan Environment and Children's Study.

Gita Nirmala Sari, Satoyo Ikehara, Kanami Tanigawa, Yoko Kawanishi, Ehab S Eshak, Tadashi Kimura, Tomotaka Sobue, Hiroyasu Iso

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Article in Environmental health and preventive medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Gita Nirmala SariDepartment of Environmental Medicine and Population Sciences, Graduate School of Medicine, Osaka University.
Satoyo IkeharaDepartment of Environmental Medicine and Population Sciences, Graduate School of Medicine, Osaka University.
Kanami TanigawaOsaka Regional Center for Japan Environment and Children's Study (JECS), Osaka University.
Yoko KawanishiOsaka Regional Center for Japan Environment and Children's Study (JECS), Osaka University.
Ehab S EshakDepartment of Environmental Medicine and Population Sciences, Graduate School of Medicine, Osaka University.
Tadashi KimuraObstetrics and Gynecology, Osaka University Graduate School of Medicine.
Tomotaka SobueDepartment of Environmental Medicine and Population Sciences, Graduate School of Medicine, Osaka University.
Hiroyasu IsoOsaka Regional Center for Japan Environment and Children's Study (JECS), Osaka University.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough the influence of maternal distress during pregnancy on newborn Apgar scores has been studied in various populations, there is limited research specifically addressing this issue among Asian women. This study of Japanese women aims to investigate the association between maternal distress during pregnancy and the risk of a low 5-min-Apgar score among newborns.

methodsWe analyzed data from 87,765 mother-newborn pairs in the Japan Environment and Children's Study. Using multivariable logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (CI) for low Apgar scores (<7) at 5 minutes about maternal distress during early and mid-late pregnancy, as measured by the Kessler Psychological Distress Scale (K6). Apgar scores were obtained from newborns' medical records.

resultsA higher risk of low Apgar score in newborns at 5 minutes was found in mothers with moderate to severe distress than in those with low distress during mid-late pregnancy. The adjusted OR (95% CI) was 1.22 (1.05-1.42) for moderate distress (K6 = 5-12) and 1.42 (1.00-2.01) for severe distress compared to low distress (p for trend = 0.002). The positive association between maternal distress and the risk of low Apgar score was observed in preterm birth (<37 weeks) and low birth weight (<2,500 g) but not in term birth and normal birth weight.

conclusionMaternal distress during mid-late pregnancy was positively associated with the risk of low Apgar score of newborns, specifically in preterm birth and low birth weight.

Indexed as

Apgar ScoreMothersPregnancy ComplicationsStress, PsychologicalAdultFemaleHumansInfant, NewbornJapanMalePregnancyRisk FactorsYoung AdultApgar scoreBirth cohortKessler Distress ScaleMaternal distress

Identifiers

PMID40240157
PMCPMC12006027

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