Evidence map›Paper›PMID 40240142›Full record

ArticleGenes & development2025

An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma.

Claudette R Fraire, Kavita Desai, Indumathy Jagadeeswaran, Uma A Obalapuram, Lindsay K Mendyka, Veena Rajaram, Teja Sebastian, Yemin Wang, Kenan Onel, Jeon Lee and 2 more

Abstract read
In one paragraph

Article in Genes & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Cancers · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Claudette R FraireDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Kavita DesaiDivision of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Indumathy JagadeeswaranDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Uma A ObalapuramDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Lindsay K MendykaGeisel School of Medicine, Dartmouth College, Hanover, New Hampshire 03755, USA.
Veena RajaramDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Teja SebastianDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Yemin WangDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z7, Canada.
Kenan OnelDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, USA.
Jeon LeeLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Stephen X SkapekDepartment of Pediatrics, Duke University, Durham, North Carolina 27710, USA.
Kenneth S ChenDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA; kenneth.chen@utsouthwestern.edu.ORCID 0000-0003-2304-4631

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7M
Developmental transcription factors in Drosha-driven cancerR01CA289259 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kenneth Sung-Man Chen · 2024 to 2026
$2.2M
The role of PLAG1 in Wilms tumor formationK08CA207849 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, KENNETH SUNG-MAN · 2017 to 2021
$781k
NCI NIH HHS K08 CA207849NCI NIH HHS P30 CA142543NCI NIH HHS R01 CA289259
6 · The paper itself

Abstract

Mutations in the microRNA processing genes

Indexed as

Brain NeoplasmsCell DifferentiationCell ProliferationMicroRNAsPinealomaAnimalsDEAD-box RNA HelicasesDNA-Binding ProteinsGene Expression Regulation, NeoplasticMicePineal GlandRibonuclease IIITranscription FactorsDEAD-box RNA HelicasesDicer1 protein, mouseDNA-Binding ProteinsDrosha protein, mouseMicroRNAsRibonuclease IIITranscription FactorsDicer1DroshamicroRNApineoblastoma

Identifiers

PMID40240142
PMCPMC12128879

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.