Evidence map›Paper›PMID 40240141›Full record

ArticleGenes & development2025

IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells.

Alexander Chen, Hannah Wang, Xuanwei Li, Corina Anastasaki, David H Gutmann

Abstract read
In one paragraph

Article in Genes & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexander ChenDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Hannah WangDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Xuanwei LiDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Corina AnastasakiDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
David H GutmannDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA gutmannd@wustl.edu.ORCID 0000-0002-3127-5045

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Defining the Mechanistic Basis for Neurofibromatosis-1 Nervous System Disease HeterogeneityR35NS097211 · NINDS · WASHINGTON UNIVERSITY · PI GUTMANN, DAVID H · 2017 to 2024
$5.7M
MOLECULAR ONCOLOGY TRAINING GRANTT32CA113275 · NCI · WASHINGTON UNIVERSITY · PI Matthew J Walter · 2006 to 2026
$5.7M
TRAINING IN REGENERATIVE MEDICINET32EB028092 · NIBIB · WASHINGTON UNIVERSITY · PI Farshid Guilak · 2020 to 2026
$2.0M
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NCI NIH HHS T32 CA113275NIBIB NIH HHS T32 EB028092NINDS NIH HHS R35 NS097211
6 · The paper itself

Abstract

The two major genomic alterations in pediatric pilocytic astrocytoma (PA) are

Indexed as

beta CateninCell ProliferationHomeodomain ProteinsNerve Tissue ProteinsNeurogliaTranscription FactorsHumansInduced Pluripotent Stem Cellsbeta CateninCTNNB1 protein, humanHomeodomain ProteinsNerve Tissue ProteinsTranscription FactorsBRAFhuman-induced pluripotent stem cellsMEKneurofibromatosis type 1β-catenin

Identifiers

PMID40240141
PMCPMC12128870

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.