SynthesisHeart (British Cardiac Society)2025
Association between programmed electrical stimulation inducibility and arrhythmic risk in hypertrophic cardiomyopathy: a systematic review and meta-analysis.
Synthesis in Heart (British Cardiac Society), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRisk stratification for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) remains challenging. Programmed electrical stimulation (PES) is not endorsed by current guidelines, and its role in risk stratification is debated. We conducted a systematic review and meta-analysis to assess the association between PES inducibility and major arrhythmic events (MAE) in patients with HCM and evaluate its predictive value.
methodsWe searched PubMed/MEDLINE, Embase and the Cochrane Library up to 1 February 2024, for studies assessing MAE (SCD, resuscitated cardiac arrest or appropriate implantable cardioverter-defibrillator interventions) according to PES inducibility. A random-effects meta-analysis was performed to calculate pooled ORs and CIs. Sensitivity, specificity and predictive values were also calculated from the published information.
resultsFive studies (587 patients, 66% male, mean age 38±14 years) were included. PES inducibility was observed in 188 (32%) patients. MAE occurred in 18% of inducible patients (34 events) and 2% of non-inducible patients (8 events) (OR 10.83, 95% CI 3.52 to 33.34, p<0.001, I²=27%). The sensitivity of PES for MAE was 81%, specificity was 72%, positive predictive value was 18%, and negative predictive value was 98%.
conclusionPES inducibility is associated with a 10 times higher risk of MAE in patients with HCM. Further prospective studies are needed to validate its independent predictive value in the context of contemporary risk stratification tools. PROSPERO REGISTRATION NUMBER: CRD42024497521.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.