Evidence map›Paper›PMID 40240063›Full record

ArticleGut2025

Precision risk stratification of primary gastric cancer after eradication of

Harumi Yamada, Seiichiro Abe, Hadrien Charvat, Takayuki Ando, Masahiro Maeda, Kazunari Murakami, Shiro Oka, Takao Maekita, Mitsushige Sugimoto, Takahisa Furuta and 15 more

Abstract readMulticenter Study
In one paragraph

Article in Gut, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Gut microbes · 2026
    Article
  4. Genes · 2026
    Article
  5. From screening to surveillance: integrated prevention ofThe Lancet regional health. Western Pacific · 2026
    Review
  6. Association ofTranslational cancer research · 2026
    Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Integrated virulence-resistance profiling ofFrontiers in cellular and infection microbiology · 2026
    Article
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Harumi YamadaDepartment of Epigenomics, Institute for Advanced Life Sciences, Hoshi University, Tokyo, Japan.ORCID 0000-0002-6619-9310
Seiichiro AbeEndoscopy Division, National Cancer Center Hospital, Tokyo, Japan.ORCID 0000-0002-2736-6921
Hadrien CharvatFaculty of International Liberal Arts, Juntendo University, Tokyo, Japan.
Takayuki AndoThird Department of Internal Medicine, University of Toyama, Toyama, Japan.
Masahiro MaedaDepartment of Gastrointestinal Surgery, Kyoto University, Kyoto, Japan.
Kazunari MurakamiDepartment of Gastroenterology, Faculty of Medicine, Oita University, Oita, Japan.
Shiro OkaDepartment of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan.ORCID 0000-0002-1652-0743
Takao MaekitaSecond Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.
Mitsushige SugimotoDivision of Digestive Endoscopy, Shiga University of Medical Science Hospital, Shiga, Japan.
Takahisa FurutaCenter for Clinical Research, Hamamatsu University School of Medicine, Shizuoka, Japan.
Mitsuru KaiseDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan.
Nobutake YamamichiDepartment of Gastroenterology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.
Hiroyuki TakamaruEndoscopy Division, National Cancer Center Hospital, Tokyo, Japan.ORCID 0000-0002-7019-6331
Akiko SasakiGastroenterology Medicine Center, Shonan Kamakura General Hospital, Kanagawa, Japan.
Ichiro OdaEndoscopy Division, National Cancer Center Hospital, Tokyo, Japan.ORCID 0000-0001-8666-127X
Sohachi NanjoThird Department of Internal Medicine, University of Toyama, Toyama, Japan.
Nobuhiro SuzukiDepartment of Internal Medicine, Joetsu General Hospital, Niigata, Japan.
Toshiro SugiyamaThird Department of Internal Medicine, University of Toyama, Toyama, Japan.
Masaaki KodamaDepartment of Gastroenterology, Faculty of Medicine, Oita University, Oita, Japan.
Kazuhiro MizukamiDepartment of Gastroenterology, Faculty of Medicine, Oita University, Oita, Japan.
Masanori ItoDepartment of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan.
Takahiro KotachiDepartment of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan.
Taichi ShimazuEpidemiology and Prevention Group, Research Center for Cancer Prevention andScreening, National Cancer Center, Tokyo, Japan.ORCID 0000-0001-6000-9830
Seiichiro YamamotoShizuoka Graduate University of Public Health, Shizuoka, Japan.
Toshikazu UshijimaDepartment of Epigenomics, Institute for Advanced Life Sciences, Hoshi University, Tokyo, Japan tushijima142@hoshi.ac.jp.ORCID 0000-0003-3405-7817

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrecision cancer risk stratification for gastric cancer is urgently needed for the growing number of healthy people after

objectiveTo confirm the clinical usefulness of a DNA methylation marker for epimutation burden, and to identify a cut-off methylation level for a super-high-risk population.

designHealthy people after

results1624 participants had at least one endoscopic follow-up with a median follow-up of 4.05 years, and a primary gastric cancer developed in 27 participants. The highest quartile of

conclusionA DNA methylation marker can risk-stratify healthy people after TRIAL REGISTRATION NUMBER: UMIN-CTR000016894.

Indexed as

DNA MethylationHelicobacter InfectionsHelicobacter pyloriStomach NeoplasmsAdultAgedFemaleHumansIncidenceMaleMiddle AgedProspective StudiesRisk AssessmentRisk FactorsBIOMARKERSEPIGENETICSGASTRIC CANCERHELICOBACTER PYLORIMETHYLATION

Identifiers

PMID40240063
PMCPMC12418579

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.