Evidence map›Paper›PMID 40239965›Full record

ArticleACS nano2025

Core-Shell Codelivery Nanocarrier Synergistically Regulates Cartilaginous Immune Microenvironment for Total Meniscus Replacement.

Yajie Wang, Bin Tang, Menghan Zhou, Bohui Li, Xujie Lu, Huaman Geng, Dan Li, Yujie Hua, Guangdong Zhou, Di Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. [Advances in immunomodulatory strategies for meniscal regeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yajie WangPlastic Surgery Institute, Shandong Provincial Key Laboratory for Tissue Regeneration and Repair & Reconstruction (Under Preparation), Shandong Second Medical University, Weifang, Shandong 261053, PR China.
Bin TangInternational Medical Department, China-Japan Friendship Hospital, Beijing 100029, P. R. China.
Menghan ZhouPlastic Surgery Institute, Shandong Provincial Key Laboratory for Tissue Regeneration and Repair & Reconstruction (Under Preparation), Shandong Second Medical University, Weifang, Shandong 261053, PR China.
Bohui LiPlastic Surgery Institute, Shandong Provincial Key Laboratory for Tissue Regeneration and Repair & Reconstruction (Under Preparation), Shandong Second Medical University, Weifang, Shandong 261053, PR China.
Xujie LuPlastic Surgery Institute, Shandong Provincial Key Laboratory for Tissue Regeneration and Repair & Reconstruction (Under Preparation), Shandong Second Medical University, Weifang, Shandong 261053, PR China.
Huaman GengPlastic Surgery Institute, Shandong Provincial Key Laboratory for Tissue Regeneration and Repair & Reconstruction (Under Preparation), Shandong Second Medical University, Weifang, Shandong 261053, PR China.
Dan LiDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Tissue Engineering, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, PR China.
Yujie HuaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Tissue Engineering, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, PR China.
Guangdong ZhouPlastic Surgery Institute, Shandong Provincial Key Laboratory for Tissue Regeneration and Repair & Reconstruction (Under Preparation), Shandong Second Medical University, Weifang, Shandong 261053, PR China.ORCID 0000-0003-2488-2733
Di WangPlastic Surgery Institute, Shandong Provincial Key Laboratory for Tissue Regeneration and Repair & Reconstruction (Under Preparation), Shandong Second Medical University, Weifang, Shandong 261053, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cartilage tissue engineering has made significant strides in clinical regenerative treatment. The success of cartilage regeneration critically depends on a favorable regenerative microenvironment by means of ideal bioactive scaffolds. However, total meniscus replacement frequently entails a harsh microenvironment of accompanying chronic inflammation and oxidative stress conditions after a massive injury, which extremely hinders tissue regenerative repair. Herein, a "core-shell" codelivery nanocarrier is developed to synergistically regulate the cartilaginous immune microenvironment (CIME) for total meniscus replacement. In this study, mesoporous silica nanoparticles are used to encapsulate an antioxidant and anti-inflammatory drug, Emodin, in the core and meanwhile modify a growth differentiation factor (GDF) by reversible disulfide bonds on the shell, together constructing a codelivery nanocarrier system (

Indexed as

CartilageDrug CarriersMeniscusNanoparticlesAnimalsAnti-Inflammatory AgentsAntioxidantsCellular MicroenvironmentRabbitsSilicon DioxideTissue EngineeringTissue ScaffoldsAnti-Inflammatory AgentsAntioxidantsDrug CarriersSilicon Dioxidecartilage tissue engineeringhydrogelsmeniscus repairmesoporous silicananomaterials

Identifiers

PMID40239965
PMCPMC12045277

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.