Evidence map›Paper›PMID 40239923›Full record

ArticleJournal of global antimicrobial resistance2025

First identification and whole-genome characterization of human-associated Enterobacter roggenkampii and Enterobacter sichuanensis carrying bla

Ricardo Gutiérrez, Tábata Elizondo-Álvarez, Manuel Ramírez-Cardoce, Francisco Duarte-Martínez, Estela Cordero-Laurent, Elvira Segura-Retana, Daniel Cascante-Serrano, Romein Walters-Mais, Roberto G Melano, María Antonieta Jiménez-Pearson

Abstract read
In one paragraph

Article in Journal of global antimicrobial resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ricardo GutiérrezCentro Nacional de Referencia de Bacteriología, Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud (Inciensa), Cartago, Costa Rica; One Health Center for Zoonoses and Tropical Infectious Diseases, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts, Saint Kitts and Nevis.
Tábata Elizondo-ÁlvarezCentro Nacional de Referencia de Bacteriología, Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud (Inciensa), Cartago, Costa Rica.
Manuel Ramírez-CardoceHospital San Juan de Dios, Caja Costarricense de Seguro Social, San José, Costa Rica.
Francisco Duarte-MartínezCentro Nacional de Referencia de Inocuidad Microbiológica de Alimentos, Laboratorio de Genómica y Biología Molecular, Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud (Inciensa), Cartago, Costa Rica.
Estela Cordero-LaurentCentro Nacional de Referencia de Inocuidad Microbiológica de Alimentos, Laboratorio de Genómica y Biología Molecular, Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud (Inciensa), Cartago, Costa Rica.
Elvira Segura-RetanaHospital San Juan de Dios, Caja Costarricense de Seguro Social, San José, Costa Rica.
Daniel Cascante-SerranoHospital San Juan de Dios, Caja Costarricense de Seguro Social, San José, Costa Rica.
Romein Walters-MaisHospital Dr. Tony Facio Castro, Caja Costarricense de Seguro Social, Limón, Costa Rica.
Roberto G MelanoPublic Health Ontario Laboratory, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada.
María Antonieta Jiménez-PearsonCentro Nacional de Referencia de Bacteriología, Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud (Inciensa), Cartago, Costa Rica. Electronic address: ajimenez@inciensa.sa.cr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAll carbapenem-resistant Gram-negative bacterial isolates obtained in the Costa Rican National Network of Bacteriology Laboratories are routinely referred to the National Reference Center for Bacteriology for the national-laboratory for the surveillance and characterization of their carbapenem-related mechanism of resistance. As a result of this healthcare-associated infection surveillance, two bacterial isolates with unknown mechanisms for carbapenem resistance were investigated.

methodsThe isolates were subjected to taxonomic identification, antimicrobial susceptibility testing, and whole-genome characterization, using Illumina and Oxford Nanopore technologies, and bioinformatic analyses.

resultsThe isolates were identified as Enterobacter roggenkampii and Enterobacter sichuanensis. Although the isolates presented different antimicrobial resistance profiles, both were resistant to carbapenems, positive for the modified carbapenem inactivation method (mCIM), and showed inhibition of carbapenem resistance with boronic acid. The full characterization of the isolates' genomes, revealed the presence of the rare chromosomal bla

conclusionsThe limited global distribution of the bla

Indexed as

Bacterial Proteinsbeta-LactamasesEnterobacterEnterobacteriaceae InfectionsGenome, BacterialAnti-Bacterial AgentsCarbapenemsCosta RicaHumansMicrobial Sensitivity TestsWhole Genome SequencingAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenemsAntibiotic resistancebla(IMI)CarbapenemasesEnterobacter

Identifiers

PMID40239923
PMCPMC12198106

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.