Evidence map›Paper›PMID 40239554›Full record

ArticleClinical neurology and neurosurgery2025

Cerebral blood flow velocities measured by transcranial doppler are associated with magnetic resonance imaging biomarkers in moyamoya arteriopathy.

Lisa R Sun, Melike Guryildirim, John R Gatti, Syed Ameen Ahmad, Wendy Ziai, Rebecca F Gottesman, Lori C Jordan, Risheng Xu, Aylin Tekes, Vivek Yedavalli

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Article in Clinical neurology and neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Lisa R SunDepartment of Neurology, The Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: lsun20@jhmi.edu.
Melike GuryildirimDepartment of Radiology, Division of Pediatric Radiology and Pediatric Neuroradiology, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
John R GattiDepartment of Neurology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Syed Ameen AhmadThe Johns Hopkins School of Medicine, Baltimore, MD, USA.
Wendy ZiaiDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Rebecca F GottesmanNational Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD, USA.
Lori C JordanDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Risheng XuDepartment of Neurosurgery, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
Aylin TekesDepartment of Radiology, Division of Pediatric Radiology and Pediatric Neuroradiology, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
Vivek YedavalliDepartment of Radiology, Division of Neuroradiology, The Johns Hopkins School of Medicine, Baltimore, MD, USA.

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
American Heart Association-American Stroke Association 850044NCATS NIH HHS UL1 TR003098
6 · The paper itself

Abstract

purposeIn individuals with moyamoya arteriopathy, transcranial Doppler (TCD) may be a useful complement to MRI because of its safety, cost effectiveness, and ability to be performed without anesthesia in children. We evaluated associations between various MR-based moyamoya biomarkers and cerebral blood flow velocity (CBFV) as measured by TCD in individuals with moyamoya.

methodsParticipants ≤ 26-years-old with moyamoya who had not had surgical revascularization underwent TCDs within 14 days of surveillance brain MRIs. Associations between MRI parameters (Suzuki scores, cerebrovascular stenosis score, ivy sign, brush sign) and CBFV of the MCA and ICA were assessed.

resultsTwenty-six TCD-MRI pairs from 16 participants were analyzed. Median participant age was 7.3 (IQR 5.9-8.9) years. No associations between CBFV and Suzuki score or cerebrovascular stenosis score were identified. There was a significant positive association between MCA CBFV and degree of MCA stenosis between 0 % and 99 % stenosis (p = 0.02). Hemispheres without ivy sign had higher MCA CBFV compared with hemispheres with ivy sign (144 cm/s v. 105 cm/s, p = 0.02). Hemispheres with brush sign had higher CBFV compared with hemispheres without brush sign in both the MCA (232 cm/s v. 122 cm/s, p = 0.009) and ICA (213 cm/s v. 131 cm/s, p = 0.03).

conclusionIn this cohort of children and young adults with moyamoya, higher MCA CBFV were associated with higher degrees of stenosis (but not complete occlusion), the presence of a brush sign, and the absence of the ivy sign. TCD may have an important role as an adjunct to traditional neuroimaging in moyamoya arteriopathy.

Indexed as

Cerebrovascular CirculationMagnetic Resonance ImagingMoyamoya DiseaseUltrasonography, Doppler, TranscranialAdolescentAdultBiomarkersBlood Flow VelocityChildChild, PreschoolFemaleHumansMaleYoung AdultBiomarkersBrush signIvy signMoyamoyaStrokeTranscranial doppler

Identifiers

PMID40239554
PMCPMC12065648

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.