Evidence map›Paper›PMID 40238943›Full record

ReviewAmerican journal of respiratory and critical care medicine2025

Evidence-based Emergency Tracheal Intubation.

Stephanie C DeMasi, Jonathan D Casey, Matthew W Semler

Abstract readReview
In one paragraph

Review in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Reply to HyderAmerican journal of respiratory and critical care medicine · 2025
    Article
  8. Emergency Intubation: A High-Stakes Procedure with Critical Gaps in Understanding Team Impact.American journal of respiratory and critical care medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stephanie C DeMasiDepartment of Emergency Medicine and.ORCID 0000-0002-4149-8955
Jonathan D CaseyDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; and.ORCID 0000-0002-0977-290X
Matthew W SemlerDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; and.ORCID 0000-0002-7664-8263

Funding

TIPS: Training in Perioperative ScienceT32GM108554 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire · 2014 to 2026
$3.7M
Bag-Mask Ventilation to PreVent Hypoxemia during Tracheal Intubation in the Emergency Department: A Clinical TrialK23HL153584 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASEY, JONATHAN DALE · 2020 to 2024
$900k
NCATS NIH HHSNHLBI NIH HHS K23 HL153584NIGMS NIH HHS T32 GM108554NIH HHS 5T32GM108554Patient-Centered Outcomes Research InstituteU.S. Department of Defense
6 · The paper itself

Abstract

Millions of critically ill adults undergo tracheal intubation in an emergency department or ICU each year, nearly 40% of whom experience hypoxemia, hypotension, or cardiac arrest during the procedure. Over the last two decades, a series of randomized trials have examined which of the tools, techniques, devices, and drugs used to perform emergency tracheal intubation improve outcomes and which are ineffective or harmful. Results of these trials have demonstrated that preoxygenation with noninvasive ventilation and administration of positive pressure ventilation between induction and laryngoscopy prevent hypoxemia during intubation, video laryngoscopy facilitates successful intubation on the first attempt and may prevent esophageal intubation, use of a stylet is superior to intubation with an endotracheal tube alone and is comparable with use of a bougie, and administration of a fluid bolus before induction does not prevent hypotension. Many additional decisions clinicians face during emergency tracheal intubation are not yet informed by rigorous evidence. Randomized trials must continue to examine systematically each aspect of this common and high-risk procedure to improve patient outcomes and bring forth an era of evidence-based emergency tracheal intubation.

Indexed as

Intubation, IntratrachealCritical IllnessEmergency Service, HospitalEvidence-Based MedicineHumansHypoxiaLaryngoscopyRandomized Controlled Trials as Topicemergency tracheal intubationinduction medicationlaryngoscopypreoxygenation

Identifiers

PMID40238943
PMCPMC12264701

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.