Evidence map›Paper›PMID 40238905›Full record

ArticleHypertension (Dallas, Tex. : 1979)2025

Placental Endocannabinoid System: Focus on Preeclampsia and Cannabis Use.

Madhavi S Harhangi, Sinno H P Simons, Hilmar H Bijma, Anna Nguyen, Tuong-Vi Nguyen, Tu'uhevaha Kaitu'u-Lino, Irwin K M Reiss, A H Jan Danser, Michelle Broekhuizen

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Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Madhavi S HarhangiDivision of Neonatology, Department of Neonatal and Pediatric Intensive Care (M.S.H., S.H.P.S., I.K.M.R., M.B.), Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-5814-1103
Sinno H P SimonsDivision of Neonatology, Department of Neonatal and Pediatric Intensive Care (M.S.H., S.H.P.S., I.K.M.R., M.B.), Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-5219-5696
Hilmar H BijmaDivision of Obstetrics and Fetal Medicine (M.S.H., H.H.B.), Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-5800-8051
Anna NguyenMercy Hospital for Women, Department of Obstetrics, Gynaecology and Newborn Health, The University of Melbourne, Australia (A.N., T.-V.N., T.K.-L.).ORCID 0009-0005-7294-9893
Tuong-Vi NguyenMercy Hospital for Women, Department of Obstetrics, Gynaecology and Newborn Health, The University of Melbourne, Australia (A.N., T.-V.N., T.K.-L.).
Tu'uhevaha Kaitu'u-LinoMercy Hospital for Women, Department of Obstetrics, Gynaecology and Newborn Health, The University of Melbourne, Australia (A.N., T.-V.N., T.K.-L.).ORCID 0000-0001-6233-9737
Irwin K M ReissDivision of Neonatology, Department of Neonatal and Pediatric Intensive Care (M.S.H., S.H.P.S., I.K.M.R., M.B.), Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-9474-6895
A H Jan DanserDivision of Pharmacology and Vascular Medicine, Department of Internal Medicine (M.S.H., A.H.J.D., M.B.), Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-5052-3585
Michelle BroekhuizenDivision of Neonatology, Department of Neonatal and Pediatric Intensive Care (M.S.H., S.H.P.S., I.K.M.R., M.B.), Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-4736-398X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe endocannabinoid system (ECS) plays an important role in the early stages of pregnancy, while cannabis use during pregnancy associates with a greater risk of preeclampsia. This study quantified the placental ECS component mRNA levels in gestational age-matched healthy pregnant women, women with preeclampsia, and women who used cannabis throughout their pregnancy. Next, it compared the effects of the endogenous ECS agonists anandamide and 2-arachidonoylglycerol with those of the cannabinoid receptor type 1 and 2 agonists HU-210 and HU-308 in chorionic plate arteries.

methodsPlacental mRNA levels were quantified by quantitative polymerase chain reaction. Vascular reactivity was studied with and without selective cannabinoid receptor type 1 and 2 antagonists.

resultsmRNA levels of 1,2-diacylglycerol lipase α, responsible for 2-arachidonoylglycerol generation, were lowered in preeclampsia, while mRNA levels of the anandamide-synthesizing enzyme

conclusionsThe ECS is disturbed in preeclampsia, and endogenous ECS agonists lose their capacity to dilate in cannabis users, while such use also diminishes NO signaling. These data provide mechanistic evidence against cannabis use during pregnancy.

Indexed as

EndocannabinoidsMarijuana UsePlacentaPre-EclampsiaAdultArachidonic AcidsFemaleGlyceridesHumansPolyunsaturated AlkamidesPregnancyReceptor, Cannabinoid, CB1RNA, MessengeranandamideArachidonic AcidsEndocannabinoidsGlyceridesglyceryl 2-arachidonatePolyunsaturated AlkamidesReceptor, Cannabinoid, CB1RNA, Messengeranandamidecannabisendocannabinoidsplacentapre-eclampsia

Identifiers

PMID40238905
PMCPMC12002044

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.