Evidence map›Paper›PMID 40238893›Full record

ArticleScience advances2025

Kinetic implications of IP

Manish Gupta, Arpa Hudait, Mark Yeager, Gregory A Voth

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Mechanistic insights into lenacapavir-induced off-pathway HIV-1 capsid assembly.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Manish GuptaDepartment of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-6879-0617
Arpa HudaitDepartment of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-4279-4000
Mark YeagerFrost Institute for Chemistry and Molecular Science, University of Miami, Coral Gables, FL 33124, USA.ORCID 0000-0002-3301-640X
Gregory A VothDepartment of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-3267-6748

Funding

Structural Biology CoreU54AI170855 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI Bruce Edward Torbett · 2022 to 2026
$36.7M
Multiscale Simulation of HIV-1 Virion Release and MaturationR01AI178850 · NIAID · UNIVERSITY OF CHICAGO · PI Gregory A. Voth · 2023 to 2026
$2.1M
Pre-clinical evaluation of alpha-Cache; a novel RNA vaccine for an emerging orthobunyavirusR21AI178550 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI AUGUSTE, ALBERT J., ERASMUS, JESSE HONG-SAE · 2023 to 2024
$469k
NIAID NIH HHS R01 AI178850NIAID NIH HHS R21 AI178550NIAID NIH HHS U54 AI170855
6 · The paper itself

Abstract

HIV-1 capsid (CA) proteins self-assemble into a fullerene-shaped CA, enabling cellular transport and nuclear entry of the viral genome. A structural switch comprising the Thr-Val-Gly- Gly (TVGG) motif either assumes a disordered coil or a 3

Indexed as

CapsidCapsid ProteinsHIV-1Phytic AcidVirus AssemblyAnionsBinding SitesHumansKineticsModels, MolecularMolecular Dynamics SimulationProtein BindingProtein ConformationProtein MultimerizationAnionsCapsid ProteinsPhytic Acid

Identifiers

PMID40238893
PMCPMC12002132

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.