ArticleScience advances2025
Amyotrophic lateral sclerosis and frontotemporal dementia mutation reduces endothelial TDP-43 and causes blood-brain barrier defects.
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Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
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Who cites it
16 citing papers in PubMed.
- Article
- Recent Advancements in Drug Delivery Across the Blood-Brain Barrier in Amyotrophic Lateral Sclerosis (ALS).CNS neuroscience & therapeutics · 2026Review
- Bridging the gap: neuroinflammation and the dawn of precision medicine in amyotrophic lateral sclerosis.Translational neurodegeneration · 2026Review
- Progranulin haploinsufficiency remodels the cerebral microvasculature and neurovascular unit.bioRxiv : the preprint server for biology · 2026Article
- Shared and disease-specific human brain vascular signatures in Alzheimer's disease, frontotemporal dementia, and Huntington's disease.bioRxiv : the preprint server for biology · 2026Article
- Review
- Lipid Messengers: Mechanisms and Clinical Applications of Exosomal Lipids in Neurodegenerative Diseases.Molecular neurobiology · 2026Review
- Accelerated brain aging in amyotrophic lateral sclerosis and its prognostic associations: a cohort study.BMC medicine · 2026Article
- Multimodal Biomarker Characterization of the ALS/FTD Spectrum: A Real-World Clinical Dataset Analysis.International journal of molecular sciences · 2025Article
- Epigenetic profiles of tissue informative CpGs inform ALS disease status and progression.Genome medicine · 2025Article
- Pulmonary Hypertension Promotes Neuroinflammation and Neurodegeneration.bioRxiv : the preprint server for biology · 2025Article
- Glymphatic activity in behavioral variant frontotemporal dementia: Link with vascular function and astrocytic activation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Blood-spinal cord barrier alterations in a mouse model of centrifugation-induced hypergravity.Frontiers in physiology · 2025Article
- "Proteinjury": a universal pathological mechanism mediated by cerebrospinal fluid in neurodegeneration and trauma.Frontiers in cell and developmental biology · 2025Review
- Brain neurovascular coupling in amyotrophic lateral sclerosis: Correlations with disease progression and cognitive impairment.European journal of neurology · 2025Article
- Establishment of a novel amyotrophic lateral sclerosis patient (Frontiers in cell and developmental biology · 2024Article
Corrections and comments
- Update of
Authors and funding
15 authors.
Ashok CheemalaCenter for Vascular Biology, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID 0000-0003-2259-2839
Amy L KimbleCenter for Vascular Biology, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID 0000-0002-0100-4906
Emily N BurrageCenter for Vascular Biology, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID 0000-0002-8263-9662
Stephen B HelmingCenter for Vascular Biology, University of Connecticut School of Medicine, Farmington, CT, USA.
Jordan D TyburskiCenter for Vascular Biology, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID 0000-0002-2450-1649
Nathan K LeclairMD/PhD Program, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID 0000-0002-0401-2549
Omar M OmarCenter for Vascular Biology, University of Connecticut School of Medicine, Farmington, CT, USA.
Aamir R ZuberiRare Disease Translational Center and Technology Evaluation and Development Laboratory, The Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0003-0252-9760
Melissa MurphyCenter for Vascular Biology, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID 0009-0002-7176-1344
Evan R JellisonDepartment of Immunology, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID 0009-0004-2674-1605
Bo ReeseCenter for Genome Innovation, University of Connecticut, Storrs, CT, USA.ORCID 0000-0001-7667-5627
Xiangyou HuDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID 0000-0002-9083-728X
Cathleen M LutzRare Disease Translational Center and Technology Evaluation and Development Laboratory, The Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0003-2502-1900
Riqiang YanDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID 0000-0001-7195-7617
Patrick A MurphyCenter for Vascular Biology, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID 0000-0002-2956-1042
Funding
Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9MThe Jackson Laboratory Center for Precision Genetics: From New Models to Novel TherapeuticsU54OD020351 · OD · JACKSON LABORATORY · PI KORSTANJE, RONNY · 2015 to 2019
$10.2MSupplement for BACE1 in neurodegeneration and neuronal dysfunctionR01NS074256 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI RIQIANG YAN · 2011 to 2026
$5.8MInhibition of BACE1 for benefiting Alzheimer's patientsR01AG046929 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI RIQIANG YAN · 2013 to 2026
$3.9MInhibition of BACE1 for benefiting Alzheimer's patientsRF1AG046929 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI YAN, RIQIANG · 2018 to 2018
$3.3MRNA-Binding Proteins in the Regulation of Vascular Inflammation and ImmunityR01HL150362 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MURPHY, PATRICK ANDRIES · 2021 to 2025
$2.7MContributions of Endothelial RNA-binding Protein Dysregulation to Blood Brain Barrier Defects and Neurodegenerative DiseaseRF1NS117449 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MURPHY, PATRICK ANDRIES · 2020 to 2020
$2.2MBACE1 in neurodegeneration and neurological dysfunctionRF1NS074256 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI YAN, RIQIANG · 2021 to 2021
$2.1MInvestigation of alternative splicing in response to low and disturbed flowR00HL125727 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MURPHY, PATRICK ANDRIES · 2016 to 2018
$746kContributions of Endothelial RNA-binding Protein Dysregulation to Blood Brain Barrier Defects and Neurodegenerative DiseaseR01NS117449 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MURPHY, PATRICK ANDRIES · 2024 to 2024
$544kInvestigation of alternative splicing in response to low and disturbed flowK99HL125727 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MURPHY, PATRICK ANDRIES · 2015 to 2016
$250kNCI NIH HHS P30 CA034196NHLBI NIH HHS K99 HL125727NHLBI NIH HHS R00 HL125727NHLBI NIH HHS R01 HL150362NIA NIH HHS R01 AG046929NIA NIH HHS RF1 AG046929NIH HHS U54 OD020351NINDS NIH HHS R01 NS074256NINDS NIH HHS R01 NS117449NINDS NIH HHS RF1 NS074256NINDS NIH HHS RF1 NS117449
Abstract
Mutations in the
Indexed as
Amyotrophic Lateral SclerosisBlood-Brain BarrierDNA-Binding ProteinsEndothelial CellsFrontotemporal DementiaMutationAnimalsBrainDisease Models, AnimalHumansMiceDNA-Binding ProteinsTARDBP protein, humanTardbp protein, mouse
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.