Evidence map›Paper›PMID 40238797›Full record

Trial reportAIDS care2025

Comparing PrEP adherence via objective and self-reported measures among fishermen working on Lake Victoria, Kenya.

Daniel O Adede, Lila A Sheira, Sarah A Gutin, Antony Ochung, Bernard Ayieko, Phoebe Olugo, Jayne Lewis-Kulzer, Edwin D Charlebois, Carol S Camlin, Harsha Thirumurthy and 3 more

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
In one paragraph

Trial report in AIDS care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04772469 (Self-Test Strategies and Linkage Incentives to Improve ART and PrEP Uptake in Men), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04772469 nacompletednot on this map

Self-Test Strategies and Linkage Incentives to Improve ART and PrEP Uptake in Men

TypeinterventionalSponsorUniversity of California, San FranciscoRan2021 to 2023Enrolled934ConditionsHuman Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, HIV Infections, Sexually Transmitted Diseases, ViralArmsProvision of multiple self-tests, Small monetary incentives, Use of SMS/text reminders to motivate adherence to ART or PrEP
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Daniel O AdedeImpact Research and Development Organization, Kisumu, Kenya.
Lila A SheiraInstitute for Health and Aging, School of Nursing, University of California, San Francisco, CA, USA.
Sarah A GutinDepartment of Community Health Systems, School of Nursing, University of California, San Francisco, CA, USA.
Antony OchungImpact Research and Development Organization, Kisumu, Kenya.
Bernard AyiekoImpact Research and Development Organization, Kisumu, Kenya.
Phoebe OlugoImpact Research and Development Organization, Kisumu, Kenya.
Jayne Lewis-KulzerDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, USA.
Edwin D CharleboisDepartment of Medicine, Division of Prevention Sciences, University of California, San Francisco, CA, USA.
Carol S CamlinDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, USA.
Harsha ThirumurthyPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kawango AgotImpact Research and Development Organization, Kisumu, Kenya.
Zachary KwenaKenya Medical Research Institute, Centre for Microbiology Research, Kisumu, Kenya.
Monica GandhiDivision of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, CA, USA.

Funding

Randomized Trial to Optimize Virologic Suppression Rates Using a Point-of-Care Urine Monitoring Assay (ROVING-PUMA)R01AI143340 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2018 to 2026
$5.6M
“Hair Lengthening”: Using Hair Levels to Interpret Long-Acting PrEP Studies.R37AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2023 to 2026
$3.2M
Self-Test Strategies and Linkage Incentives to Improve ART and PrEP Uptake in MenR01MH120176 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CAMLIN, CAROL SUZANNE, THIRUMURTHY, HARSHA · 2019 to 2023
$3.1M
Couples Advancing Together for Safer Conception (CAT-SC): A couples’-based intervention to improve engagement in sexual and reproductive health services for mobile fisherfolk in KenyaK01MH132435 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sarah A Gutin · 2023 to 2026
$721k
NIAID NIH HHS R01 AI143340NIAID NIH HHS R37 AI098472NIMH NIH HHS K01 MH132435NIMH NIH HHS R01 MH120176
6 · The paper itself

Abstract

Fishermen working along Lake Victoria experience high rates of HIV acquisition that can be mitigated by pre-exposure prophylaxis (PrEP), which requires adequate adherence for effective prevention. We evaluated PrEP adherence among Kenyan fishermen using objective metrics and examine non-adherence. Data are from the Owete study (NCT04772469), a cluster randomized-controlled trial using a social network approach among fishermen to increase HIV testing and linkage to care. Survey and lab data were collected from PrEP users. We measured recent objective adherence via a point-of-care tenofovir urine assay. We conducted a logistic regression to assess the relationship between self-reported adherence data and urine tenofovir detection. Among 71 PrEP users, 34% self-reported ≥90% PrEP adherence. Reasons for non-adherence included not feeling at risk (31%), being away and without medication (27%), or feeling they did not need PrEP (24%). Detectable PrEP in urine was low (17%). Self-reported PrEP non-adherence within 30 days was associated with 13.29 times the odds of non-detection of urine tenofovir (95% CI: 2.20, 80.43). The point-of-care tenofovir assay was a valuable tool for objectively measuring PrEP adherence. Interventions to bolster PrEP adherence are needed to prevent HIV acquisition among fishermen, as are longer-acting products with lower demands for adherence.

Indexed as

Anti-HIV AgentsHIV InfectionsMedication AdherencePre-Exposure ProphylaxisTenofovirAdultFemaleHumansKenyaMaleMiddle AgedSelf ReportAnti-HIV AgentsTenofovirAdherencefishermenHIV preventionPrEPSDG 10: reduced inequalitiesSDG3: good health and well-beingurine assay

Identifiers

PMID40238797
PMCPMC12090886

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.